Linked Life Data

16997552

Source:http://linkedlifedata.com/resource/pubmed/id/16997552

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2006-11-19
pubmed:abstractText
Isobrassinin (2-(S-methyldithiocarbamoylaminomethyl)indole (7a), a regioisomer of the cruciferous phytoalexin brassinin (1), exerted marked antiproliferative effects on the HeLa, A431 and MCF7 cell lines (>78.6% inhibition at 30muM). For structure-activity relationships, further analogues were synthesized. The highest cytotoxic effect was displayed by 2-phenylimino-1,3-thiazino[5,6-b]indole (10) (10 microM, 76.8%-HeLa and 46.3%-MCF7). The effect of the natural phytoalexin brassinin was also determined.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6273-6
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Isobrassinin and its analogues: novel types of antiproliferative agents.
pubmed:affiliation
Institute of Pharmaceutical Chemistry, University of Szeged and Research Group for Heterocyclic Chemistry, Hungarian Academy of Sciences, H-6701, PO Box 427, Hungary.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't