|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003209,
umls-concept:C0012634,
umls-concept:C0020792,
umls-concept:C0035647,
umls-concept:C0087111,
umls-concept:C0205314,
umls-concept:C0221912,
umls-concept:C0279516,
umls-concept:C0441655,
umls-concept:C0679622,
umls-concept:C1515999
|
|
pubmed:issue |
23
|
|
pubmed:dateCreated |
2006-11-10
|
|
pubmed:abstractText |
A series of borinic acid picolinate esters were synthesized and screened for their minimum inhibitory concentration (MIC) against Gram-positive and -negative bacteria. Our lead compounds were then screened for anti-inflammatory activity. From these studies, we identified 3-hydroxypyridine-2-carbonyloxy-bis(3-chloro-4-methylphenyl)borane (2g, AN0128) as having the best combination of anti-bacterial and anti-inflammatory activities. This compound is now in clinical development for dermatological conditions.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:AkamaTsutomuT,
pubmed-author:BakerStephen JSJ,
pubmed-author:BenkovicStephen JSJ,
pubmed-author:KhanJehangirJ,
pubmed-author:KullyMaureenM,
pubmed-author:MaplesKirk RKR,
pubmed-author:PanditChetanC,
pubmed-author:PlattnerJacob JJJ,
pubmed-author:SauroVittorioV,
pubmed-author:SinghRajeshwarR,
pubmed-author:VialL JLJJr,
pubmed-author:ZhangYong-KangYK
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5963-7
|
|
pubmed:meshHeading |
pubmed-meshheading:16997550-Anti-Bacterial Agents,
pubmed-meshheading:16997550-Anti-Inflammatory Agents,
pubmed-meshheading:16997550-Boranes,
pubmed-meshheading:16997550-Boron,
pubmed-meshheading:16997550-Boron Compounds,
pubmed-meshheading:16997550-Cytokines,
pubmed-meshheading:16997550-Esters,
pubmed-meshheading:16997550-Humans,
pubmed-meshheading:16997550-Leukocytes,
pubmed-meshheading:16997550-Molecular Structure,
pubmed-meshheading:16997550-Pyridines,
pubmed-meshheading:16997550-Skin Diseases,
pubmed-meshheading:16997550-Structure-Activity Relationship
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases.
|
|
pubmed:affiliation |
Anacor Pharmaceuticals, Inc., 1060 E. Meadow Circle, Palo Alto, CA 94303, USA. sbaker@anacor.com <sbaker@anacor.com>
|
|
pubmed:publicationType |
Journal Article
|
