| pubmed-article:16997283 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16997283 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:16997283 | lifeskim:mentions | umls-concept:C0059239 | lld:lifeskim |
| pubmed-article:16997283 | lifeskim:mentions | umls-concept:C1565434 | lld:lifeskim |
| pubmed-article:16997283 | lifeskim:mentions | umls-concept:C0920425 | lld:lifeskim |
| pubmed-article:16997283 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:16997283 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16997283 | pubmed:dateCreated | 2007-2-2 | lld:pubmed |
| pubmed-article:16997283 | pubmed:abstractText | Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in signal transduction pathways that are initiated at sites of integrin-mediated cell adhesions and by growth factor receptors. FAK is a key regulator of survival, proliferation, migration and invasion: processes that are all involved in the development and progression of cancer. FAK is also linked to oncogenes at both a biochemical and functional level. Moreover, overexpression and/or increased activity of FAK is common in a wide variety of human cancers, implicating a role for FAK in carcinogenesis. Given the important role of FAK in a large number of processes involved in tumorigenesis, metastasis and survival signalling FAK should be regarded as a potential target in the development of anti-cancer drugs. Therefore, selective inhibitors of FAK need to be developed. Combination of these selective FAK inhibitors with cytotoxic agents could be a very promising anti-cancer therapy. | lld:pubmed |
| pubmed-article:16997283 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16997283 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997283 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16997283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997283 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997283 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16997283 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16997283 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:16997283 | pubmed:author | pubmed-author:van de... | lld:pubmed |
| pubmed-article:16997283 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:16997283 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16997283 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16997283 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:16997283 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16997283 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16997283 | pubmed:pagination | 597-609 | lld:pubmed |
| pubmed-article:16997283 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16997283 | pubmed:meshHeading | pubmed-meshheading:16997283... | lld:pubmed |
| pubmed-article:16997283 | pubmed:meshHeading | pubmed-meshheading:16997283... | lld:pubmed |
| pubmed-article:16997283 | pubmed:meshHeading | pubmed-meshheading:16997283... | lld:pubmed |
| pubmed-article:16997283 | pubmed:meshHeading | pubmed-meshheading:16997283... | lld:pubmed |
| pubmed-article:16997283 | pubmed:meshHeading | pubmed-meshheading:16997283... | lld:pubmed |
| pubmed-article:16997283 | pubmed:meshHeading | pubmed-meshheading:16997283... | lld:pubmed |
| pubmed-article:16997283 | pubmed:meshHeading | pubmed-meshheading:16997283... | lld:pubmed |
| pubmed-article:16997283 | pubmed:meshHeading | pubmed-meshheading:16997283... | lld:pubmed |
| pubmed-article:16997283 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:16997283 | pubmed:articleTitle | Focal adhesion kinase: a potential target in cancer therapy. | lld:pubmed |
| pubmed-article:16997283 | pubmed:affiliation | Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands. | lld:pubmed |
| pubmed-article:16997283 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16997283 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:16997283 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16997283 | lld:pubmed |
