| pubmed-article:16997276 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16997276 | lifeskim:mentions | umls-concept:C0599779 | lld:lifeskim |
| pubmed-article:16997276 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:16997276 | lifeskim:mentions | umls-concept:C0007193 | lld:lifeskim |
| pubmed-article:16997276 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:16997276 | lifeskim:mentions | umls-concept:C0053799 | lld:lifeskim |
| pubmed-article:16997276 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:16997276 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:16997276 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16997276 | pubmed:dateCreated | 2006-10-4 | lld:pubmed |
| pubmed-article:16997276 | pubmed:abstractText | Oxidative stress is an important susceptibility factor for dilated cardiomyopathy. We have investigated the effects of bisoprolol, a beta1-selective adrenoceptor blocker, on oxidative stress and the development of cardiac dysfunction in a model of dilated cardiomyopathy. Male TO-2 and control hamsters at 8 weeks of age were treated with bisoprolol (5 mg/kg per day) or vehicle for 4 weeks. Treatment with bisoprolol prevented the progression of cardiac dysfunction in TO-2 hamsters. This drug did not affect the increase in NADPH oxidase activity but prevented the reduction in activity and expression of mitochondrial manganese-dependent superoxide dismutase as well as the increases in the concentrations of interleukin-1beta and tumor necrosis factor-alpha in the left ventricle of TO-2 hamsters. Attenuation of the development of cardiac dysfunction by bisoprolol may thus result in part from normalization of the associated increases in the levels of oxidative stress and pro-inflammatory cytokines in the left ventricle. | lld:pubmed |
| pubmed-article:16997276 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16997276 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997276 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16997276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16997276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16997276 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16997276 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16997276 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16997276 | pubmed:author | pubmed-author:OikawaShinjiS | lld:pubmed |
| pubmed-article:16997276 | pubmed:author | pubmed-author:YamadaYoshiji... | lld:pubmed |
| pubmed-article:16997276 | pubmed:author | pubmed-author:IwaseMitsunor... | lld:pubmed |
| pubmed-article:16997276 | pubmed:author | pubmed-author:YokotaMitsuhi... | lld:pubmed |
| pubmed-article:16997276 | pubmed:author | pubmed-author:IchiharaGakuG | lld:pubmed |
| pubmed-article:16997276 | pubmed:author | pubmed-author:KanazawaHiroa... | lld:pubmed |
| pubmed-article:16997276 | pubmed:author | pubmed-author:IchiharaSahok... | lld:pubmed |
| pubmed-article:16997276 | pubmed:author | pubmed-author:KatoYosukeY | lld:pubmed |
| pubmed-article:16997276 | pubmed:author | pubmed-author:HashimotoKats... | lld:pubmed |
| pubmed-article:16997276 | pubmed:author | pubmed-author:MatsushitaAya... | lld:pubmed |
| pubmed-article:16997276 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16997276 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:16997276 | pubmed:volume | 350 | lld:pubmed |
| pubmed-article:16997276 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16997276 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16997276 | pubmed:pagination | 105-13 | lld:pubmed |
| pubmed-article:16997276 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:16997276 | pubmed:meshHeading | pubmed-meshheading:16997276... | lld:pubmed |
| pubmed-article:16997276 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16997276 | pubmed:articleTitle | Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy. | lld:pubmed |
| pubmed-article:16997276 | pubmed:affiliation | Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan. saho@gene.mie-u.ac.jp | lld:pubmed |
| pubmed-article:16997276 | pubmed:publicationType | Journal Article | lld:pubmed |
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