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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-10-4
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pubmed:abstractText |
Oxidative stress is an important susceptibility factor for dilated cardiomyopathy. We have investigated the effects of bisoprolol, a beta1-selective adrenoceptor blocker, on oxidative stress and the development of cardiac dysfunction in a model of dilated cardiomyopathy. Male TO-2 and control hamsters at 8 weeks of age were treated with bisoprolol (5 mg/kg per day) or vehicle for 4 weeks. Treatment with bisoprolol prevented the progression of cardiac dysfunction in TO-2 hamsters. This drug did not affect the increase in NADPH oxidase activity but prevented the reduction in activity and expression of mitochondrial manganese-dependent superoxide dismutase as well as the increases in the concentrations of interleukin-1beta and tumor necrosis factor-alpha in the left ventricle of TO-2 hamsters. Attenuation of the development of cardiac dysfunction by bisoprolol may thus result in part from normalization of the associated increases in the levels of oxidative stress and pro-inflammatory cytokines in the left ventricle.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitrotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/4-hydroxy-2-nonenal,
http://linkedlifedata.com/resource/pubmed/chemical/Aldehydes,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Bisoprolol,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
350
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-13
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16997276-Aldehydes,
pubmed-meshheading:16997276-Animals,
pubmed-meshheading:16997276-Antioxidants,
pubmed-meshheading:16997276-Bisoprolol,
pubmed-meshheading:16997276-Blood Pressure,
pubmed-meshheading:16997276-Body Weight,
pubmed-meshheading:16997276-Cardiomyopathy, Dilated,
pubmed-meshheading:16997276-Cricetinae,
pubmed-meshheading:16997276-Disease Models, Animal,
pubmed-meshheading:16997276-Echocardiography,
pubmed-meshheading:16997276-Fibrosis,
pubmed-meshheading:16997276-Glutathione,
pubmed-meshheading:16997276-Heart Failure,
pubmed-meshheading:16997276-Heart Rate,
pubmed-meshheading:16997276-Interleukin-1,
pubmed-meshheading:16997276-Isoenzymes,
pubmed-meshheading:16997276-Male,
pubmed-meshheading:16997276-NADPH Oxidase,
pubmed-meshheading:16997276-Organ Size,
pubmed-meshheading:16997276-Oxidative Stress,
pubmed-meshheading:16997276-Superoxide Dismutase,
pubmed-meshheading:16997276-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16997276-Tyrosine,
pubmed-meshheading:16997276-Ventricular Function, Left
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pubmed:year |
2006
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pubmed:articleTitle |
Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy.
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pubmed:affiliation |
Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan. saho@gene.mie-u.ac.jp
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pubmed:publicationType |
Journal Article
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