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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-12
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pubmed:abstractText |
In a primate model of postnatal virus transmission, we have previously shown that 1 h post-exposure prophylaxis (PEP) with a triple combination of neutralizing monoclonal antibodies (nmAbs) conferred sterilizing protection to neonatal macaques against oral challenge with pathogenic simian-human immunodeficiency virus (SHIV). Here, we show that nmAbs can also partially protect SHIV-exposed newborn macaques against infection or disease, when given as 12 or 24 h PEP, respectively. This work delineates the potential and the limits of passive immunoprophylaxis with nmAbs. Even though 24 h PEP with nmAbs did not provide sterilizing immunity to neonatal monkeys, it contained viremia and protected infants from acute disease. Taken together with our results from other PEP studies, these data show that the success of passive immunization depends on the nmAb potency/dose and the time window between virus exposure and start of immunotherapy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0042-6822
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pubmed:author |
pubmed-author:AndersonDaniel CDC,
pubmed-author:BuckleyKathleen AKA,
pubmed-author:CavaciniLisa ALA,
pubmed-author:ChalmersAlistairA,
pubmed-author:FerrantelliFlaviaF,
pubmed-author:Hofmann-LehmannReginaR,
pubmed-author:KatingerHermannH,
pubmed-author:LiPei-LinPL,
pubmed-author:McClureHarold MHM,
pubmed-author:MontefioriDavid CDC,
pubmed-author:RasmussenRobert ARA,
pubmed-author:RuprechtRuth MRM,
pubmed-author:StieglerGabrielaG,
pubmed-author:WangTaoT,
pubmed-author:WilliamsAlison LAL
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
358
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-78
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16996554-Animals,
pubmed-meshheading:16996554-Animals, Newborn,
pubmed-meshheading:16996554-Antibodies, Monoclonal,
pubmed-meshheading:16996554-Antibodies, Viral,
pubmed-meshheading:16996554-CD4 Lymphocyte Count,
pubmed-meshheading:16996554-Disease Models, Animal,
pubmed-meshheading:16996554-HIV Antibodies,
pubmed-meshheading:16996554-HIV Infections,
pubmed-meshheading:16996554-Immunity, Cellular,
pubmed-meshheading:16996554-Immunization, Passive,
pubmed-meshheading:16996554-Macaca mulatta,
pubmed-meshheading:16996554-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:16996554-Simian immunodeficiency virus,
pubmed-meshheading:16996554-Survival Analysis,
pubmed-meshheading:16996554-Time Factors,
pubmed-meshheading:16996554-Viral Load,
pubmed-meshheading:16996554-Viremia
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pubmed:year |
2007
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pubmed:articleTitle |
Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques.
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pubmed:affiliation |
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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