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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-1-23
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pubmed:abstractText |
Post-streptococcal autoimmune inflammation of basal ganglia was suggested to be an etiological factor in some cases of Tourette syndrome (TS). Since regulatory T (T reg) cells play a major role in preventing autoimmunity, we hypothesized that a defect in T reg cells may be present in children with TS. We also postulated that group A beta hemolytic streptococcal infections could promote autoimmune responses by releasing exotoxins (streptococcal pyrogenic exotoxins [SPE]).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-3223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16996487-Adolescent,
pubmed-meshheading:16996487-Age of Onset,
pubmed-meshheading:16996487-Antigens, CD,
pubmed-meshheading:16996487-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:16996487-Autoantigens,
pubmed-meshheading:16996487-Blood Cell Count,
pubmed-meshheading:16996487-CD4 Lymphocyte Count,
pubmed-meshheading:16996487-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16996487-Child,
pubmed-meshheading:16996487-Data Interpretation, Statistical,
pubmed-meshheading:16996487-Female,
pubmed-meshheading:16996487-Flow Cytometry,
pubmed-meshheading:16996487-Humans,
pubmed-meshheading:16996487-Immune Tolerance,
pubmed-meshheading:16996487-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:16996487-Lectins, C-Type,
pubmed-meshheading:16996487-Lymphocyte Count,
pubmed-meshheading:16996487-Male,
pubmed-meshheading:16996487-Streptococcal Infections,
pubmed-meshheading:16996487-T-Lymphocytes,
pubmed-meshheading:16996487-Tic Disorders,
pubmed-meshheading:16996487-Tourette Syndrome
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pubmed:year |
2007
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pubmed:articleTitle |
Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study.
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pubmed:affiliation |
Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, USA. ivana.kawikova@yale.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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