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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-11-1
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pubmed:abstractText |
The neurons of the lateral hypothalamus that contain hypocretin/orexin (hcrt/orx) are thought to promote arousal through the excitatory action they exert on the multiple areas to which they project within the CNS. We show here that the hcrt/orx peptides can also exert a strong action on the amygdala, a structure known for its implication in emotional aspects of behavior. Indeed, the hcrt/orx peptides, applied in acute rat brain slices, excite a specific class of "low threshold burst" neurons in the central medial (CeM) nucleus which is considered as a major output of the amygdala. These excitatory effects are postsynaptic, mediated by Hcrt2/OX2 receptors and result from the closure of a potassium conductance. They occur on a class of neurons that are also excited by vasopressin acting through V1a receptors. These results suggest that the hcrt/orx system can act through the amygdala to augment arousal and evoke the autonomic and behavioral responses associated with fear, stress or emotion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vasopressin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasopressins,
http://linkedlifedata.com/resource/pubmed/chemical/orexin receptors,
http://linkedlifedata.com/resource/pubmed/chemical/orexins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0306-4522
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
999-1004
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pubmed:meshHeading |
pubmed-meshheading:16996221-Action Potentials,
pubmed-meshheading:16996221-Amygdala,
pubmed-meshheading:16996221-Animals,
pubmed-meshheading:16996221-Arousal,
pubmed-meshheading:16996221-Excitatory Postsynaptic Potentials,
pubmed-meshheading:16996221-Fear,
pubmed-meshheading:16996221-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16996221-Neural Pathways,
pubmed-meshheading:16996221-Neurons,
pubmed-meshheading:16996221-Neuropeptides,
pubmed-meshheading:16996221-Organ Culture Techniques,
pubmed-meshheading:16996221-Potassium Channels,
pubmed-meshheading:16996221-Rats,
pubmed-meshheading:16996221-Receptors, G-Protein-Coupled,
pubmed-meshheading:16996221-Receptors, Neuropeptide,
pubmed-meshheading:16996221-Receptors, Vasopressin,
pubmed-meshheading:16996221-Stress, Psychological,
pubmed-meshheading:16996221-Synaptic Transmission,
pubmed-meshheading:16996221-Vasopressins
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pubmed:year |
2006
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pubmed:articleTitle |
Excitatory action of hypocretin/orexin on neurons of the central medial amygdala.
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pubmed:affiliation |
Département des Neurosciences Fondamentales, Centre Médical Universitaire, 1 rue Michel-Servet, 1211 Genève 4, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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