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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2006-11-10
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pubmed:abstractText |
We studied the role of fasudil, a selective Rho-kinase inhibitor, in experimental autoimmune encephalomyelitis (EAE). Both parenteral and oral administration of fasudil prevented the development of EAE induced by proteolipid protein (PLP) p139-151 in SJL/J mice. Specific proliferation of lymphocytes to PLP was significantly reduced, together with a downregulation of interleukin (IL)-17 and a marked decrease of the IFN-gamma/IL-4 ratio. Immunohistochemical examination also disclosed a marked decrease of inflammatory cell infiltration, and attenuated demyelination and acute axonal transaction. These results may provide a rationale of selective blockade of Rho-kinase by oral use of fasudil as a new therapy for multiple sclerosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(5-Isoquinolinesulfonyl)-2-Methylp...,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteolipid Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/fasudil,
http://linkedlifedata.com/resource/pubmed/chemical/myelin proteolipid protein (139-151),
http://linkedlifedata.com/resource/pubmed/chemical/rho-Associated Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
126-34
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pubmed:dateRevised |
2011-8-26
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pubmed:meshHeading |
pubmed-meshheading:16996142-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:16996142-Animals,
pubmed-meshheading:16996142-Central Nervous System,
pubmed-meshheading:16996142-Chemotaxis, Leukocyte,
pubmed-meshheading:16996142-Disease Models, Animal,
pubmed-meshheading:16996142-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:16996142-Female,
pubmed-meshheading:16996142-Immunosuppression,
pubmed-meshheading:16996142-Inflammation Mediators,
pubmed-meshheading:16996142-Interferon-gamma,
pubmed-meshheading:16996142-Interleukin-17,
pubmed-meshheading:16996142-Interleukin-4,
pubmed-meshheading:16996142-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16996142-Lymphocyte Activation,
pubmed-meshheading:16996142-Lymphocytes,
pubmed-meshheading:16996142-Mice,
pubmed-meshheading:16996142-Myelin Proteolipid Protein,
pubmed-meshheading:16996142-Nerve Fibers, Myelinated,
pubmed-meshheading:16996142-Neuroprotective Agents,
pubmed-meshheading:16996142-Peptide Fragments,
pubmed-meshheading:16996142-Protein Kinase Inhibitors,
pubmed-meshheading:16996142-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16996142-Treatment Outcome,
pubmed-meshheading:16996142-Wallerian Degeneration,
pubmed-meshheading:16996142-rho-Associated Kinases
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pubmed:year |
2006
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pubmed:articleTitle |
The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.
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pubmed:affiliation |
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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