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pubmed-article:16990552pubmed:abstractTextLipopolysaccharide (LPS) interacts with toll-like receptor 4 (TLR4) and induces proliferation of vascular smooth muscle cells (VSMCs) which plays a causal role in atherogenesis. The role of TLR4 expression and regulation in LPS-stimulated VSMCs remains unclear. TLR4 mRNAs often contain AU-rich elements (AREs) in their 3' untranslated regions (3'UTR) which have a high affinity for RNA-binding proteins. It is not know whether the RNA-binding protein, human antigen R (HuR), regulates TLR4 expression in human aortic smooth muscle cells (HASMCs).lld:pubmed
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pubmed-article:16990552pubmed:articleTitleThe role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation.lld:pubmed
pubmed-article:16990552pubmed:affiliationGraduate Institute of Medical Sciences, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan.lld:pubmed
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