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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0014264,
umls-concept:C0021368,
umls-concept:C0035696,
umls-concept:C0035820,
umls-concept:C0085177,
umls-concept:C0086418,
umls-concept:C0086597,
umls-concept:C0205263,
umls-concept:C0205314,
umls-concept:C0441712,
umls-concept:C0679622,
umls-concept:C1314939,
umls-concept:C1411976,
umls-concept:C1801960
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pubmed:issue |
12
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pubmed:dateCreated |
2006-11-19
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pubmed:abstractText |
Lipopolysaccharide (LPS) interacts with toll-like receptor 4 (TLR4) and induces proliferation of vascular smooth muscle cells (VSMCs) which plays a causal role in atherogenesis. The role of TLR4 expression and regulation in LPS-stimulated VSMCs remains unclear. TLR4 mRNAs often contain AU-rich elements (AREs) in their 3' untranslated regions (3'UTR) which have a high affinity for RNA-binding proteins. It is not know whether the RNA-binding protein, human antigen R (HuR), regulates TLR4 expression in human aortic smooth muscle cells (HASMCs).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/ELAVL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Endotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2622-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16990552-Animals,
pubmed-meshheading:16990552-Antigens, Surface,
pubmed-meshheading:16990552-Aorta,
pubmed-meshheading:16990552-Atherosclerosis,
pubmed-meshheading:16990552-Cells, Cultured,
pubmed-meshheading:16990552-Endotoxins,
pubmed-meshheading:16990552-Gene Expression Regulation,
pubmed-meshheading:16990552-Humans,
pubmed-meshheading:16990552-Lipopolysaccharides,
pubmed-meshheading:16990552-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:16990552-Muscle, Smooth, Vascular,
pubmed-meshheading:16990552-NADPH Oxidase,
pubmed-meshheading:16990552-RNA, Messenger,
pubmed-meshheading:16990552-RNA, Small Interfering,
pubmed-meshheading:16990552-RNA Interference,
pubmed-meshheading:16990552-RNA-Binding Proteins,
pubmed-meshheading:16990552-Rabbits,
pubmed-meshheading:16990552-Signal Transduction,
pubmed-meshheading:16990552-Toll-Like Receptor 4,
pubmed-meshheading:16990552-Tunica Intima
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pubmed:year |
2006
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pubmed:articleTitle |
The role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation.
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pubmed:affiliation |
Graduate Institute of Medical Sciences, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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