Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5794
pubmed:dateCreated
2006-9-22
pubmed:abstractText
Abnormally synchronized synaptic transmission in the brain causes epilepsy. Most inherited forms of epilepsy result from mutations in ion channels. However, one form of epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF), is characterized by mutations in a secreted neuronal protein, LGI1. We show that ADAM22, a transmembrane protein that when mutated itself causes seizure, serves as a receptor for LGI1. LGI1 enhances AMPA receptor-mediated synaptic transmission in hippocampal slices. The mutated form of LGI1 fails to bind to ADAM22. ADAM22 is anchored to the postsynaptic density by cytoskeletal scaffolds containing stargazin. These studies in rat brain indicate possible avenues for understanding human epilepsy.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/ADAM Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Adam22 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Adam22 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Cacng2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels, http://linkedlifedata.com/resource/pubmed/chemical/Dlgh4 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Ligands, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/alpha-Amino-3-hydroxy-5-methyl-4-iso...
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
22
pubmed:volume
313
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1792-5
pubmed:dateRevised
2010-6-17
pubmed:meshHeading
pubmed-meshheading:16990550-ADAM Proteins, pubmed-meshheading:16990550-Animals, pubmed-meshheading:16990550-Calcium Channels, pubmed-meshheading:16990550-Cell Line, pubmed-meshheading:16990550-Cerebellar Cortex, pubmed-meshheading:16990550-Cerebral Cortex, pubmed-meshheading:16990550-Epilepsies, Partial, pubmed-meshheading:16990550-Hippocampus, pubmed-meshheading:16990550-Humans, pubmed-meshheading:16990550-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:16990550-Ligands, pubmed-meshheading:16990550-Membrane Proteins, pubmed-meshheading:16990550-Mice, pubmed-meshheading:16990550-N-Methylaspartate, pubmed-meshheading:16990550-Nerve Tissue Proteins, pubmed-meshheading:16990550-Protein Binding, pubmed-meshheading:16990550-Protein Structure, Tertiary, pubmed-meshheading:16990550-Proteins, pubmed-meshheading:16990550-Rats, pubmed-meshheading:16990550-Receptors, AMPA, pubmed-meshheading:16990550-Recombinant Fusion Proteins, pubmed-meshheading:16990550-Synapses, pubmed-meshheading:16990550-Synaptic Transmission, pubmed-meshheading:16990550-Transfection, pubmed-meshheading:16990550-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
pubmed:year
2006
pubmed:articleTitle
Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.
pubmed:affiliation
Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't