Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-11-19
pubmed:abstractText
The potential combined effect and mechanism of calcium channel blockers (CCB) and angiotensin II type 1 receptor blockers (ARB) to improve insulin resistance were investigated in type 2 diabetic KK-Ay mice, focusing on their antioxidative action. Treatment of KK-Ay mice with a CCB, azelnidipine (3 mg/kg/day), or with an ARB, olmesartan (3 mg/kg/day), for 2 weeks lowered the plasma concentrations of glucose and insulin in the fed state, attenuated the increase in plasma glucose in the oral glucose tolerance test (OGTT), and increased 2-[(3)H]deoxy-d-glucose (2-[(3)H]DG) uptake into skeletal muscle with the increase in translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Both blockers also decreased the in situ superoxide production in skeletal muscle. The decrease in plasma concentrations of glucose and insulin in the fed state and superoxide production in skeletal muscle, as well as GLUT4 translocation to the plasma membrane, after azelnidipine administration was not significantly affected by coadministration of an antioxidant, 2,2,6,6-tetramethyl-1-piperidinyloxy (tempol). However, those changes caused by olmesartan were further improved by tempol. Moreover, olmesartan enhanced the insulin-induced tyrosine phosphorylation of insulin receptor substrate-1 induced in skeletal muscle, whereas azelnidipine did not change it. Coadministration of azelnidipine and olmesartan further decreased the plasma concentrations of glucose and insulin, improved OGTT, and increased 2-[(3)H]DG uptake in skeletal muscle. These results suggest that azelnidipine improved glucose intolerance mainly through inhibition of oxidative stress and enhanced the inhibitory effects of olmesartan on glucose intolerance, as well as the clinical possibility that the combination of CCB and ARB could be more effective than monotherapy in the treatment of insulin resistance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor..., http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants, http://linkedlifedata.com/resource/pubmed/chemical/Azetidinecarboxylic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose, http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic N-Oxides, http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose, http://linkedlifedata.com/resource/pubmed/chemical/Dihydropyridines, http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 4, http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Insulin, http://linkedlifedata.com/resource/pubmed/chemical/Insulin Receptor Substrate Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Irs1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Spin Labels, http://linkedlifedata.com/resource/pubmed/chemical/Superoxides, http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles, http://linkedlifedata.com/resource/pubmed/chemical/azelnidipine, http://linkedlifedata.com/resource/pubmed/chemical/olmesartan, http://linkedlifedata.com/resource/pubmed/chemical/tempol
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
319
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1081-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:16990512-Angiotensin II Type 1 Receptor Blockers, pubmed-meshheading:16990512-Animals, pubmed-meshheading:16990512-Antimetabolites, pubmed-meshheading:16990512-Antioxidants, pubmed-meshheading:16990512-Azetidinecarboxylic Acid, pubmed-meshheading:16990512-Blood Glucose, pubmed-meshheading:16990512-Calcium Channel Blockers, pubmed-meshheading:16990512-Cyclic N-Oxides, pubmed-meshheading:16990512-Deoxyglucose, pubmed-meshheading:16990512-Diabetes Mellitus, Type 2, pubmed-meshheading:16990512-Dihydropyridines, pubmed-meshheading:16990512-Glucose Intolerance, pubmed-meshheading:16990512-Glucose Tolerance Test, pubmed-meshheading:16990512-Glucose Transporter Type 4, pubmed-meshheading:16990512-Imidazoles, pubmed-meshheading:16990512-Insulin, pubmed-meshheading:16990512-Insulin Receptor Substrate Proteins, pubmed-meshheading:16990512-Male, pubmed-meshheading:16990512-Mice, pubmed-meshheading:16990512-Mice, Inbred C57BL, pubmed-meshheading:16990512-Oxidative Stress, pubmed-meshheading:16990512-Phosphoproteins, pubmed-meshheading:16990512-Spin Labels, pubmed-meshheading:16990512-Superoxides, pubmed-meshheading:16990512-Tetrazoles
pubmed:year
2006
pubmed:articleTitle
Calcium channel blocker azelnidipine reduces glucose intolerance in diabetic mice via different mechanism than angiotensin receptor blocker olmesartan.
pubmed:affiliation
Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Shitsukawa, Tohon, Ehime 791-0295, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't