16990001

Source:http://linkedlifedata.com/resource/pubmed/id/16990001

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0164786, umls-concept:C0205460, umls-concept:C0220781, umls-concept:C0220825, umls-concept:C0243077, umls-concept:C1883254
pubmed:issue	23
pubmed:dateCreated	2006-11-10
pubmed:abstractText	A series of 5-arylamino-6-chloro-1H-indazole-4,7-diones were synthesized and evaluated for their inhibitory activity on protein kinase B/Akt. The compounds exhibited a potent Akt1 inhibitory activity. Further mechanistic study revealed that they might have dual inhibitory effects on both activity and phosphorylation of Akt1 in PC-3 tumor cell line.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Chlorine, http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Indazoles, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0960-894X
pubmed:author	pubmed-author:KimTae-YongTY, pubmed-author:KoJong HeeJH, pubmed-author:ParkRae-EunRE, pubmed-author:RyuChung-KyuCK, pubmed-author:RyuJung SuJS, pubmed-author:SongEun-HaEH, pubmed-author:YeonSeung WooSW, pubmed-author:YouHea-JungHJ
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	16
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	6001-5
pubmed:dateRevised	2011-11-2
pubmed:meshHeading	pubmed-meshheading:16990001-Amination, pubmed-meshheading:16990001-Animals, pubmed-meshheading:16990001-Antineoplastic Agents, pubmed-meshheading:16990001-Catalysis, pubmed-meshheading:16990001-Cell Line, Tumor, pubmed-meshheading:16990001-Chlorine, pubmed-meshheading:16990001-Glycogen Synthase Kinase 3, pubmed-meshheading:16990001-Humans, pubmed-meshheading:16990001-Indazoles, pubmed-meshheading:16990001-Mice, pubmed-meshheading:16990001-Mice, Nude, pubmed-meshheading:16990001-Molecular Structure, pubmed-meshheading:16990001-Neoplasms, pubmed-meshheading:16990001-Phosphorylation, pubmed-meshheading:16990001-Protein Kinase Inhibitors, pubmed-meshheading:16990001-Proto-Oncogene Proteins c-akt, pubmed-meshheading:16990001-Structure-Activity Relationship, pubmed-meshheading:16990001-Xenograft Model Antitumor Assays
pubmed:year	2006
pubmed:articleTitle	Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt.
pubmed:affiliation	ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd., 260-5, Eonnam-Dong, Kuseong-Gu, Yongin, Kyongki-Do 449-910, Republic of Korea.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't