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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
15
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pubmed:dateCreated |
2006-9-21
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|
pubmed:abstractText |
Fifty-five patients placed on tipranavir/ritonavir 500/200 mg twice a day (27 with enfuvirtide and 28 without) underwent tipranavir and ritonavir plasma concentration measurements by high-pressure liquid chromatography. Markedly higher tipranavir and ritonavir trough concentrations were observed in enfuvirtide recipients. The modelling of sparse plasma samples using a first order absorption and elimination monocompartmental model without time lag predicted higher tipranavir elimination half-life and volume of distribution in enfuvirtide takers. This unexpected drug-drug interaction warrants further investigation.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0269-9370
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
|
|
pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1977-9
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pubmed:meshHeading |
pubmed-meshheading:16988521-Anti-HIV Agents,
pubmed-meshheading:16988521-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:16988521-Cohort Studies,
pubmed-meshheading:16988521-Drug Interactions,
pubmed-meshheading:16988521-Female,
pubmed-meshheading:16988521-HIV Envelope Protein gp41,
pubmed-meshheading:16988521-HIV Fusion Inhibitors,
pubmed-meshheading:16988521-HIV Infections,
pubmed-meshheading:16988521-HIV Protease Inhibitors,
pubmed-meshheading:16988521-HIV-1,
pubmed-meshheading:16988521-Half-Life,
pubmed-meshheading:16988521-Humans,
pubmed-meshheading:16988521-Male,
pubmed-meshheading:16988521-Peptide Fragments,
pubmed-meshheading:16988521-Pyridines,
pubmed-meshheading:16988521-Pyrones,
pubmed-meshheading:16988521-Ritonavir
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|
pubmed:year |
2006
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|
pubmed:articleTitle |
Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide.
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|
pubmed:affiliation |
Department of Infectious Diseases, University of Turin, Turin, Italy.
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pubmed:publicationType |
Journal Article
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