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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-10-23
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pubmed:abstractText |
Circulating KL-6 is a specific indicator of pulmonary injury affecting the alveolar epithelium and interstitium. Our preliminary study suggested the usefulness of plasma KL-6 as a marker of bronchopulmonary dysplasia (BPD). To confirm the diagnostic value of KL-6 for BPD as well as to determine the reference range, we conducted a larger prospective study in 135 preterm infants <32 wk GA. Among the infants without oxygen dependence at a postconceptional age of 36 wk, the plasma KL-6 level showed no significant association with GA at any time. Among 42 infants <28 wk GA, plasma KL-6 levels were significantly higher in those with moderate/severe BPD compared with those with no/mild BPD. A plasma level of 199 U/mL at 1 wk or 232 U/mL at 2 wk was an excellent predictor of moderate/severe BPD <28 wk GA (positive predictive value of 83% and 80%, respectively). Unlike nonspecific markers of inflammation or fibrosis, KL-6 objectively reflects the severity of pulmonary injury irrespective of the treatment or the radiographic changes. Therefore, not only as a good marker, measurement of KL-6 may also help to provide new insights into the pathogenesis of BPD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0031-3998
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pubmed:author |
pubmed-author:BanRyoichiR,
pubmed-author:HasegawaMasashiM,
pubmed-author:HiraSeigoS,
pubmed-author:HiranoKazuyaK,
pubmed-author:HiroiMayoM,
pubmed-author:KimHan-SukHS,
pubmed-author:MorinobuTakaoT,
pubmed-author:OgawaSatoruS,
pubmed-author:OgiharaTohruT,
pubmed-author:OueShinyaS,
pubmed-author:YamaokaShigeoS,
pubmed-author:YasuiMasakoM
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
613-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16988187-Antigens, Neoplasm,
pubmed-meshheading:16988187-Biological Markers,
pubmed-meshheading:16988187-Bronchopulmonary Dysplasia,
pubmed-meshheading:16988187-Female,
pubmed-meshheading:16988187-Fetal Blood,
pubmed-meshheading:16988187-Gestational Age,
pubmed-meshheading:16988187-Humans,
pubmed-meshheading:16988187-Infant, Newborn,
pubmed-meshheading:16988187-Infant, Premature,
pubmed-meshheading:16988187-Male,
pubmed-meshheading:16988187-Mucin-1,
pubmed-meshheading:16988187-Mucins,
pubmed-meshheading:16988187-Predictive Value of Tests,
pubmed-meshheading:16988187-Pregnancy,
pubmed-meshheading:16988187-ROC Curve,
pubmed-meshheading:16988187-Reference Values,
pubmed-meshheading:16988187-Reproducibility of Results
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pubmed:year |
2006
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pubmed:articleTitle |
Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia.
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pubmed:affiliation |
Department of Neonatal Medicine, Perinatal Center, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan. ped025@poh.osaka-med.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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