Linked Life Data

16987424

Source:http://linkedlifedata.com/resource/pubmed/id/16987424

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pubmed-article:16987424pubmed:abstractTextControl of cytosolic calcium plays a key role in airway myocyte function. Changes in intracellular Ca2+ stores can modulate contractile responses, modulate proliferation and regulate synthetic activity. Influx of Ca2+ in non excitable smooth muscle is believed to be predominantly through store operated channels (SOC) or receptor operated channels (ROC). Whereas agonists can activate both SOC and ROC in a range of smooth muscle types, the specific trigger for SOC activation is depletion of the sarcoplasmic reticulum Ca2+ stores. The mechanism underlying SOC activation following depletion of intracellular Ca2+ stores in smooth muscle has not been identified.lld:pubmed
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pubmed-article:16987424pubmed:articleTitleA key role for STIM1 in store operated calcium channel activation in airway smooth muscle.lld:pubmed
pubmed-article:16987424pubmed:affiliationDivision of Therapeutics and Molecular Medicine, University Hospital, Queens Medical Centre, Nottingham, UK. msxsp@nottingham.ac.uklld:pubmed
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