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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-9-29
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pubmed:abstractText |
Control of cytosolic calcium plays a key role in airway myocyte function. Changes in intracellular Ca2+ stores can modulate contractile responses, modulate proliferation and regulate synthetic activity. Influx of Ca2+ in non excitable smooth muscle is believed to be predominantly through store operated channels (SOC) or receptor operated channels (ROC). Whereas agonists can activate both SOC and ROC in a range of smooth muscle types, the specific trigger for SOC activation is depletion of the sarcoplasmic reticulum Ca2+ stores. The mechanism underlying SOC activation following depletion of intracellular Ca2+ stores in smooth muscle has not been identified.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-10885434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-11004585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-11463338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-11792627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-11846609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-11896026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-12871853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-15612955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-15866891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-15866892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-16005298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-16208375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-16537481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-1663158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-6270629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-8397092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16987424-9377559
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16987424-Bronchi,
pubmed-meshheading:16987424-Calcium Channels,
pubmed-meshheading:16987424-Cell Adhesion Molecules,
pubmed-meshheading:16987424-Cells, Cultured,
pubmed-meshheading:16987424-Humans,
pubmed-meshheading:16987424-Membrane Proteins,
pubmed-meshheading:16987424-Muscle, Smooth,
pubmed-meshheading:16987424-Neoplasm Proteins,
pubmed-meshheading:16987424-RNA, Small Interfering,
pubmed-meshheading:16987424-Respiratory Mucosa,
pubmed-meshheading:16987424-Stromal Cells
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pubmed:year |
2006
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pubmed:articleTitle |
A key role for STIM1 in store operated calcium channel activation in airway smooth muscle.
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pubmed:affiliation |
Division of Therapeutics and Molecular Medicine, University Hospital, Queens Medical Centre, Nottingham, UK. msxsp@nottingham.ac.uk
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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