|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
21
|
|
pubmed:dateCreated |
1990-11-21
|
|
pubmed:abstractText |
Considering the possibility to overcome drug resistance by other treatment strategies than chemotherapy we investigated the susceptibility of three independently selected multidrug-resistant sublines of the T-lymphoblastoid leukemic cell line CCRF-CEM to lymphokine-activated killer (LAK) cells. We found that two of the multidrug-resistant sublines were significantly less susceptible targets to LAK cells. A third one, however, was as susceptible as the parental CCRF-CEM cell line. Moreover, a multidrug-resistant subline that reverted to an almost drug-sensitive phenotype was observed to be also revertant for resistance against LAK cells. We found an inverse relationship between the expression of the mdr1 gene (P-glycoprotein) and the susceptibility to LAK cells. Verapamil, a calcium channel blocker, while increasing the drug sensitivity of a multidrug-resistant subline, did not induce a reversal of the suppression of LAK susceptibility. The possibility of enhanced resistance to LAK cells of multidrug-resistant cells should be taken into account when one is looking for therapy strategies to overcome multidrug resistance.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD15,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD7,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Verapamil
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0008-5472
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
50
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6793-9
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1698543-Antigens, CD15,
pubmed-meshheading:1698543-Antigens, CD45,
pubmed-meshheading:1698543-Antigens, CD7,
pubmed-meshheading:1698543-Antigens, Differentiation,
pubmed-meshheading:1698543-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1698543-Drug Resistance,
pubmed-meshheading:1698543-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:1698543-Histocompatibility Antigens,
pubmed-meshheading:1698543-Humans,
pubmed-meshheading:1698543-Immunotherapy, Adoptive,
pubmed-meshheading:1698543-Interleukin-2,
pubmed-meshheading:1698543-Killer Cells, Lymphokine-Activated,
pubmed-meshheading:1698543-Leukemia,
pubmed-meshheading:1698543-Membrane Glycoproteins,
pubmed-meshheading:1698543-P-Glycoprotein,
pubmed-meshheading:1698543-Phenotype,
pubmed-meshheading:1698543-Tumor Cells, Cultured,
pubmed-meshheading:1698543-Verapamil
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
Susceptibility of multidrug-resistant human leukemia cell lines to human interleukin 2-activated killer cells.
|
|
pubmed:affiliation |
Department of Hematology and Oncology, Children's University Hospital, Tuebingen, West Germany.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
