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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-27
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pubmed:abstractText |
The chronic lymphocytic leukemia (CLL) immunoglobulin repertoire is biased and characterized by the existence of subsets of cases with closely homologous ("stereotyped") complementarity-determining region 3 (CDR3) sequences. In the present series, 201 (21.9%) of 916 patients with CLL expressed IGHV genes that belonged to 1 of 48 different subsets of sequences with stereotyped heavy chain (H) CDR3. Twenty-six subsets comprised 3 or more sequences and were considered "confirmed." The remaining subsets comprised pairs of sequences and were considered "potential"; public database CLL sequences were found to be members of 9 of 22 "potential" subsets, thereby allowing us to consider them also "confirmed." The chance of belonging to a subset exceeded 35% for unmutated or selected IGHV genes (eg, IGHV1-69/3-21/4-39). Comparison to non-CLL public database sequences showed that HCDR3 restriction is "CLL-related." CLL cases with selected stereotyped immunoglobulins (IGs) were also found to share unique biologic and clinical features. In particular, cases expressing stereotyped IGHV4-39/IGKV1-39-1D-39 and IGHV4-34/IGKV2-30 were always IgG-switched. In addition, IGHV4-34/IGKV2-30 patients were younger and followed a strikingly indolent disease, contrasting other patients (eg, those expressing IGHV3-21/IGLV3-21) who experienced an aggressive disease, regardless of IGHV mutations. These findings suggest that a particular antigen-binding site can be critical in determining the clinical features and outcome for at least some CLL patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-4971
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pubmed:author |
pubmed-author:AnagnostopoulosAchillesA,
pubmed-author:BelessiChrysoulaC,
pubmed-author:BelhoulLyndaL,
pubmed-author:BoschFrancescF,
pubmed-author:BoudjograhMyriamM,
pubmed-author:Caligaris-CappioFedericoF,
pubmed-author:CrespoMartaM,
pubmed-author:DaviFrédéricF,
pubmed-author:DighieroGuillaumeG,
pubmed-author:FassasAthanasiosA,
pubmed-author:GhiaPaoloP,
pubmed-author:GuidaGiuseppeG,
pubmed-author:HadzidimitriouAnastasiaA,
pubmed-author:LaoutarisNikolaosN,
pubmed-author:Merle-BéralHélèneH,
pubmed-author:MontserratEmiliE,
pubmed-author:MorenoCarolC,
pubmed-author:SmilevskaTatjanaT,
pubmed-author:StamatopoulosKostasK,
pubmed-author:StavroyianniNikiN,
pubmed-author:StellaStefaniaS,
pubmed-author:SuttonLaurentL
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259-70
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pubmed:dateRevised |
2007-12-27
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pubmed:meshHeading |
pubmed-meshheading:16985177-Amino Acid Sequence,
pubmed-meshheading:16985177-Antigens, CD38,
pubmed-meshheading:16985177-B-Lymphocyte Subsets,
pubmed-meshheading:16985177-Base Sequence,
pubmed-meshheading:16985177-Cohort Studies,
pubmed-meshheading:16985177-Epitopes,
pubmed-meshheading:16985177-Follow-Up Studies,
pubmed-meshheading:16985177-France,
pubmed-meshheading:16985177-Gene Frequency,
pubmed-meshheading:16985177-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:16985177-Genes, Immunoglobulin,
pubmed-meshheading:16985177-Greece,
pubmed-meshheading:16985177-Humans,
pubmed-meshheading:16985177-Immunoglobulin Class Switching,
pubmed-meshheading:16985177-Immunoglobulin Heavy Chains,
pubmed-meshheading:16985177-Immunoglobulin Switch Region,
pubmed-meshheading:16985177-Immunoglobulin Variable Region,
pubmed-meshheading:16985177-Italy,
pubmed-meshheading:16985177-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:16985177-Molecular Sequence Data,
pubmed-meshheading:16985177-Polymerase Chain Reaction,
pubmed-meshheading:16985177-Rheumatoid Factor,
pubmed-meshheading:16985177-Sequence Homology,
pubmed-meshheading:16985177-Somatic Hypermutation, Immunoglobulin,
pubmed-meshheading:16985177-Spain
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pubmed:year |
2007
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pubmed:articleTitle |
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations.
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pubmed:affiliation |
Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Multicenter Study
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