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rdf:type |
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lifeskim:mentions |
umls-concept:C0005682,
umls-concept:C0026820,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205409,
umls-concept:C0205464,
umls-concept:C0205976,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1709059,
umls-concept:C2911692
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pubmed:issue |
4
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pubmed:dateCreated |
1990-11-19
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pubmed:abstractText |
1. Toluene diisocyanate produced concentration-dependent contractions of the rat isolated urinary bladder. 2. The contractions were tetrodotoxin-resistant and were abolished by previous exposure of the strips to capsaicin. 3. Indomethacin (5 microM) and ruthenium red (30 microM) inhibited toluene diisocyanate-induced contractions. Responses expressed as a percentage of the response obtained with substance P, 30 nM, were respectively 141.6 +/- 24.8% and 20.1 +/- 5.1% in control and indomethacin-treated strips (P less than 0.005); 123.0 +/- 30.2% and 14.0 +/- 6.5% in control and ruthenium red-treated strips (0.01 less than P less than 0.05). 4. These results suggest that toluene diisocyanate-induced contractions of the rat isolated bladder are the result of the release of cyclo-oxygenase products which may act by activating the capsaicin receptor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-2440357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-2475829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-2479880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-2482448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-2482812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-2873221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-3040835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-3132608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-3162418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-3278943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1698499-3289963
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
886-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1698499-Animals,
pubmed-meshheading:1698499-Atropine,
pubmed-meshheading:1698499-Capsaicin,
pubmed-meshheading:1698499-Indomethacin,
pubmed-meshheading:1698499-Male,
pubmed-meshheading:1698499-Methylprednisolone,
pubmed-meshheading:1698499-Muscle, Smooth,
pubmed-meshheading:1698499-Muscle Contraction,
pubmed-meshheading:1698499-Rats,
pubmed-meshheading:1698499-Rats, Inbred Strains,
pubmed-meshheading:1698499-Ruthenium Red,
pubmed-meshheading:1698499-Tetrodotoxin,
pubmed-meshheading:1698499-Toluene 2,4-Diisocyanate,
pubmed-meshheading:1698499-Urinary Bladder
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pubmed:year |
1990
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pubmed:articleTitle |
Pharmacological modulation of the contractile response to toluene diisocyanate in the rat isolated urinary bladder.
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pubmed:affiliation |
Institute of Occupational Medicine, University of Padua, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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