Linked Life Data

16983711

Source:http://linkedlifedata.com/resource/pubmed/id/16983711

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
39
pubmed:dateCreated
2006-10-9
pubmed:abstractText
Every single day, the DNA of each cell in the human body is mutated thousands of times, even in absence of oncogenes or extreme radiation. Many of these mutations could lead to cancer and, finally, death. To fight this, multicellular organisms have evolved an efficient control system with the tumor-suppressor protein p53 as the central element. An intact p53 network ensures that DNA damage is detected early on. The importance of p53 for preventing cancer is highlighted by the fact that p53 is inactivated in more than 50 % of all human tumors. Thus, for good reason, p53 is one of the most intensively studied proteins. Despite the great effort that has been made to characterize this protein, the complex function and the structural properties of p53 are still only partially known. This review highlights basic concepts and recent progress in understanding the structure and regulation of p53, focusing on emerging new mechanistic and therapeutic concepts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1433-7851
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6440-60
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
p53--a natural cancer killer: structural insights and therapeutic concepts.
pubmed:affiliation
Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't