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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2006-10-23
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pubmed:abstractText |
Growth factor receptors and cell signaling factors play a crucial role in human carcinomas and have been studied in ovarian tumors with varying results. Cell signaling involves multiple pathways and a myriad of factors that can be mutated or amplified. Cell signaling is driven through the mammalian target of rapamycin (mTOR) and extracellular regulated kinase (ERK) pathways and by some downstream molecules, such as 4E binding protein 1 (4EBP1), eukaryotic initiation factor 4E, and p70 ribosomal protein S6 kinase (p70S6K). The objectives of this study were to analyze the real role that these pathways play in ovarian cancer, to correlate them with clinicopathologic characteristics, and to identify the factors that transmit individual proliferation signals and are associated with pathologic grade and prognosis, regardless specific oncogenic alterations upstream.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
2006 American Cancer Society
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1801-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16983702-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:16983702-Adult,
pubmed-meshheading:16983702-Aged,
pubmed-meshheading:16983702-Aged, 80 and over,
pubmed-meshheading:16983702-Female,
pubmed-meshheading:16983702-Follow-Up Studies,
pubmed-meshheading:16983702-Humans,
pubmed-meshheading:16983702-Middle Aged,
pubmed-meshheading:16983702-Neoplasm Recurrence, Local,
pubmed-meshheading:16983702-Oncogene Protein v-akt,
pubmed-meshheading:16983702-Ovarian Neoplasms,
pubmed-meshheading:16983702-Phosphoproteins,
pubmed-meshheading:16983702-Phosphorylation,
pubmed-meshheading:16983702-Prognosis,
pubmed-meshheading:16983702-Receptor, Epidermal Growth Factor,
pubmed-meshheading:16983702-Receptor, erbB-2,
pubmed-meshheading:16983702-Signal Transduction,
pubmed-meshheading:16983702-Survival Analysis
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pubmed:year |
2006
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pubmed:articleTitle |
Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer.
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pubmed:affiliation |
Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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