| pubmed-article:16982883 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C1423633 | lld:lifeskim |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C0056912 | lld:lifeskim |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16982883 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:16982883 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16982883 | pubmed:dateCreated | 2006-9-19 | lld:pubmed |
| pubmed-article:16982883 | pubmed:abstractText | Bacterial CpG-containing (CpG) DNA promotes survival of murine macrophages and triggers production of proinflammatory mediators. The CpG DNA-induced inflammatory response is mediated via TLR9, whereas a recent study reported that activation of the Akt prosurvival pathway occurs via DNA-dependent protein kinase (DNA-PK) and independently of TLR9. We show, in this study, that Akt activation and survival of murine bone marrow-derived macrophages (BMM) triggered by CpG-containing phosphodiester oligodeoxynucleotides or CpG-containing phosphorothioate oligodeoxynucleotides was completely dependent on TLR9. In addition, survival triggered by CpG-containing phosphodiester oligodeoxynucleotides was not compromised in BMM from SCID mice that express a catalytically inactive form of DNA-PK. CpG DNA-induced survival of BMM was inhibited by the PI3K inhibitor, LY294002, but not by the MEK1/2 inhibitor, PD98059. The effect of LY294002 was specific to survival, because treatment of BMM with LY294002 affected CpG DNA-induced TNF-alpha production only modestly. Therefore, CpG DNA activates macrophage survival via TLR9 and the PI3K-Akt pathway and independently of DNA-PK and MEK-ERK. | lld:pubmed |
| pubmed-article:16982883 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16982883 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982883 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16982883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16982883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982883 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16982883 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16982883 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16982883 | pubmed:author | pubmed-author:HumeDavid ADA | lld:pubmed |
| pubmed-article:16982883 | pubmed:author | pubmed-author:SweetMatthew... | lld:pubmed |
| pubmed-article:16982883 | pubmed:author | pubmed-author:SesterDavid... | lld:pubmed |
| pubmed-article:16982883 | pubmed:author | pubmed-author:StaceyKatryn... | lld:pubmed |
| pubmed-article:16982883 | pubmed:author | pubmed-author:RobertsTara... | lld:pubmed |
| pubmed-article:16982883 | pubmed:author | pubmed-author:GoodridgeHele... | lld:pubmed |
| pubmed-article:16982883 | pubmed:author | pubmed-author:TrieuAngelaA | lld:pubmed |
| pubmed-article:16982883 | pubmed:author | pubmed-author:BrionKristian... | lld:pubmed |
| pubmed-article:16982883 | pubmed:author | pubmed-author:DunnJasmynJ | lld:pubmed |
| pubmed-article:16982883 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16982883 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16982883 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:16982883 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16982883 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16982883 | pubmed:pagination | 4473-80 | lld:pubmed |
| pubmed-article:16982883 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:16982883 | pubmed:meshHeading | pubmed-meshheading:16982883... | lld:pubmed |
| pubmed-article:16982883 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16982883 | pubmed:articleTitle | CpG DNA activates survival in murine macrophages through TLR9 and the phosphatidylinositol 3-kinase-Akt pathway. | lld:pubmed |
| pubmed-article:16982883 | pubmed:affiliation | Cooperative Research Centre for Chronic Inflammatory Diseases and Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia. | lld:pubmed |
| pubmed-article:16982883 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16982883 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:81897 | entrezgene:pubmed | pubmed-article:16982883 | lld:entrezgene |
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