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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-9-19
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pubmed:abstractText |
The prerequisites of peripheral activation of self-specific CD4(+) T cells that determine the development of autoimmunity are incompletely understood. SJL mice immunized with myelin proteolipid protein (PLP) 139-151 developed experimental autoimmune encephalomyelitis (EAE) when pertussis toxin (PT) was injected at the time of immunization but not when injected 6 days later, indicating that PT-induced alterations of the peripheral immune response lead to the development of autoimmunity. Further analysis using IA(s)/PLP(139-151) tetramers revealed that PT did not change effector T cell activation or regulatory T cell numbers but enhanced IFN-gamma production by self-specific CD4(+) T cells. In addition, PT promoted the generation of CD4(+)CD62L(low) effector T cells in vivo. Upon adoptive transfer, these cells were more potent than CD4(+)CD62L(high) cells in inducing autoimmunity in recipient mice. The generation of this population was paralleled by higher expression of the costimulatory molecules CD80, CD86, and B7-DC, but not B7-RP, PD-1, and B7-H1 on CD11c(+)CD4(+) dendritic cells whereas CD11c(+)CD8alpha(+) dendritic cells were not altered. Collectively, these data demonstrate the induction of autoimmunity by specific in vivo expansion of CD4(+)CD62L(low) cells and indicate that CD4(+)CD62L(low) effector T cells and CD11c(+)CD4(+) dendritic cells may be attractive targets for immune interventions to treat autoimmune diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11c,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/L-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteolipid Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Pdcd1lg2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Ligand 2...,
http://linkedlifedata.com/resource/pubmed/chemical/myelin proteolipid protein (139-151)
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4384-90
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16982873-Adjuvants, Immunologic,
pubmed-meshheading:16982873-Adoptive Transfer,
pubmed-meshheading:16982873-Animals,
pubmed-meshheading:16982873-Antigens, CD11c,
pubmed-meshheading:16982873-Antigens, CD80,
pubmed-meshheading:16982873-Antigens, CD86,
pubmed-meshheading:16982873-Autoimmunity,
pubmed-meshheading:16982873-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16982873-Cell Differentiation,
pubmed-meshheading:16982873-Dendritic Cells,
pubmed-meshheading:16982873-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:16982873-Flow Cytometry,
pubmed-meshheading:16982873-Immune Tolerance,
pubmed-meshheading:16982873-L-Selectin,
pubmed-meshheading:16982873-Lymphocyte Activation,
pubmed-meshheading:16982873-Mice,
pubmed-meshheading:16982873-Myelin Proteolipid Protein,
pubmed-meshheading:16982873-Peptide Fragments,
pubmed-meshheading:16982873-Pertussis Toxin,
pubmed-meshheading:16982873-Programmed Cell Death 1 Ligand 2 Protein
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pubmed:year |
2006
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pubmed:articleTitle |
Induction of autoimmunity by expansion of autoreactive CD4+CD62Llow cells in vivo.
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pubmed:affiliation |
Hertie Institute for Clinical Brain Research, Department of General Neurology, University of Tübingen, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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