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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-9-19
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pubmed:abstractText |
CD3(-)CD4(+)CD45(+) inducer cells are required for the initiation of mucosa-associated organogenesis of both nasopharynx-associated lymphoid tissues (NALT) and Peyer's patches (PP) in the aerodigestive tract. CXCL13(-/-) mice and mice carrying the paucity of lymph node T cell (plt) mutation and lacking expression of CCL19 and CCL21 accumulate CD3(-)CD4(+)CD45(+) cells at the site of NALT but not of PP genesis. Although NALT was observed to develop in adult CXCL13(-/-) and plt/plt mice, the formation of germinal centers in CXCL13(-/-) mice was affected, and their population of B cells was much lower than in the NALT of CXCL13(+/-) mice. Similarly, fewer T cells were observed in the NALT of plt/plt mice than in control mice. These findings indicate that the initiation of NALT organogenesis is independent of CXCL13, CCL19, and CCL21. However, the expression of these lymphoid chemokines is essential for the maturation of NALT microarchitecture.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl19 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl21c protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL19,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL21,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL13,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl13 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4276-80
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16982861-Animals,
pubmed-meshheading:16982861-Antigens, CD3,
pubmed-meshheading:16982861-Antigens, CD4,
pubmed-meshheading:16982861-Antigens, CD45,
pubmed-meshheading:16982861-B-Lymphocytes,
pubmed-meshheading:16982861-Chemokine CCL19,
pubmed-meshheading:16982861-Chemokine CCL21,
pubmed-meshheading:16982861-Chemokine CXCL13,
pubmed-meshheading:16982861-Chemokines,
pubmed-meshheading:16982861-Chemokines, CC,
pubmed-meshheading:16982861-Chemokines, CXC,
pubmed-meshheading:16982861-Embryo, Mammalian,
pubmed-meshheading:16982861-Flow Cytometry,
pubmed-meshheading:16982861-Germinal Center,
pubmed-meshheading:16982861-Immunohistochemistry,
pubmed-meshheading:16982861-Lymphoid Tissue,
pubmed-meshheading:16982861-Mice,
pubmed-meshheading:16982861-Mice, Inbred BALB C,
pubmed-meshheading:16982861-Mice, Inbred C57BL,
pubmed-meshheading:16982861-Mice, Mutant Strains,
pubmed-meshheading:16982861-Nasopharynx,
pubmed-meshheading:16982861-Organogenesis,
pubmed-meshheading:16982861-Peyer's Patches,
pubmed-meshheading:16982861-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16982861-T-Lymphocytes
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pubmed:year |
2006
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pubmed:articleTitle |
Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis.
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pubmed:affiliation |
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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