| pubmed-article:16982773 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16982773 | lifeskim:mentions | umls-concept:C0032854 | lld:lifeskim |
| pubmed-article:16982773 | lifeskim:mentions | umls-concept:C0280324 | lld:lifeskim |
| pubmed-article:16982773 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:16982773 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:16982773 | lifeskim:mentions | umls-concept:C0008897 | lld:lifeskim |
| pubmed-article:16982773 | lifeskim:mentions | umls-concept:C1514475 | lld:lifeskim |
| pubmed-article:16982773 | lifeskim:mentions | umls-concept:C1561558 | lld:lifeskim |
| pubmed-article:16982773 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:16982773 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:16982773 | pubmed:dateCreated | 2006-9-19 | lld:pubmed |
| pubmed-article:16982773 | pubmed:abstractText | We have investigated the role of antigen-processing machinery (APM) component defects in HLA class I antigen down-regulation in laryngeal squamous cell carcinoma (SCC) lesions and assessed the clinical significance of these defects. To this end, 63 formalin-fixed, paraffin-embedded tumor lesions were examined for APM component and HLA class I antigen expression by immunohistochemistry. Calnexin, calreticulin, and ERp57 were down-regulated in approximately 25% of the lesions tested, whereas LMP2, TAP1, tapasin, and HLA class I antigens were down-regulated in at least 70% of the lesions tested. LMP2 and tapasin expression was significantly correlated with HLA class I antigen expression suggesting APM component defects as a mechanism underlying HLA class I antigen down-regulation in laryngeal SCC lesions. The expression of most APM components and HLA class I antigens was correlated with the extent of CD8+ T cell infiltration into tumor lesions. Furthermore, LMP2 and HLA class I antigen down-regulation and low CD8+ T cell infiltration were significantly associated with reduced patients' survival. Multivariate analysis identified HLA class I antigen down-regulation as an independent unfavorable prognostic marker. This association is likely to reflect the reduction in the extent of CD8+ T cell infiltration in laryngeal SCC lesions. | lld:pubmed |
| pubmed-article:16982773 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982773 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982773 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982773 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16982773 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16982773 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16982773 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16982773 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16982773 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:16982773 | pubmed:author | pubmed-author:FerroneSoldan... | lld:pubmed |
| pubmed-article:16982773 | pubmed:author | pubmed-author:HarabuchiYasu... | lld:pubmed |
| pubmed-article:16982773 | pubmed:author | pubmed-author:MiyokawaNaoyu... | lld:pubmed |
| pubmed-article:16982773 | pubmed:author | pubmed-author:KatayamaAkihi... | lld:pubmed |
| pubmed-article:16982773 | pubmed:author | pubmed-author:OginoTakeshiT | lld:pubmed |
| pubmed-article:16982773 | pubmed:author | pubmed-author:IshiiHideyuki... | lld:pubmed |
| pubmed-article:16982773 | pubmed:author | pubmed-author:ShigyoHiroshi... | lld:pubmed |
| pubmed-article:16982773 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16982773 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16982773 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:16982773 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16982773 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16982773 | pubmed:pagination | 9281-9 | lld:pubmed |
| pubmed-article:16982773 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:16982773 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16982773 | pubmed:articleTitle | HLA class I antigen down-regulation in primary laryngeal squamous cell carcinoma lesions as a poor prognostic marker. | lld:pubmed |
| pubmed-article:16982773 | pubmed:affiliation | Department of Otolaryngology-Head and Neck Surgery, Division of Surgical Pathology, Asahikawa Medical College Hospital, Asahikawa, Japan. | lld:pubmed |
| pubmed-article:16982773 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16982773 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16982773 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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