Source:http://linkedlifedata.com/resource/pubmed/id/16982773
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
18
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| pubmed:dateCreated |
2006-9-19
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| pubmed:abstractText |
We have investigated the role of antigen-processing machinery (APM) component defects in HLA class I antigen down-regulation in laryngeal squamous cell carcinoma (SCC) lesions and assessed the clinical significance of these defects. To this end, 63 formalin-fixed, paraffin-embedded tumor lesions were examined for APM component and HLA class I antigen expression by immunohistochemistry. Calnexin, calreticulin, and ERp57 were down-regulated in approximately 25% of the lesions tested, whereas LMP2, TAP1, tapasin, and HLA class I antigens were down-regulated in at least 70% of the lesions tested. LMP2 and tapasin expression was significantly correlated with HLA class I antigen expression suggesting APM component defects as a mechanism underlying HLA class I antigen down-regulation in laryngeal SCC lesions. The expression of most APM components and HLA class I antigens was correlated with the extent of CD8+ T cell infiltration into tumor lesions. Furthermore, LMP2 and HLA class I antigen down-regulation and low CD8+ T cell infiltration were significantly associated with reduced patients' survival. Multivariate analysis identified HLA class I antigen down-regulation as an independent unfavorable prognostic marker. This association is likely to reflect the reduction in the extent of CD8+ T cell infiltration in laryngeal SCC lesions.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/LMP-2 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0008-5472
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
66
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
9281-9
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| pubmed:dateRevised |
2007-12-3
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| pubmed:meshHeading |
pubmed-meshheading:16982773-Adult,
pubmed-meshheading:16982773-Aged,
pubmed-meshheading:16982773-Aged, 80 and over,
pubmed-meshheading:16982773-Antibodies, Monoclonal,
pubmed-meshheading:16982773-Antibody Specificity,
pubmed-meshheading:16982773-Antigen Presentation,
pubmed-meshheading:16982773-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16982773-Carcinoma, Squamous Cell,
pubmed-meshheading:16982773-Cysteine Endopeptidases,
pubmed-meshheading:16982773-Down-Regulation,
pubmed-meshheading:16982773-Female,
pubmed-meshheading:16982773-HLA-A Antigens,
pubmed-meshheading:16982773-Humans,
pubmed-meshheading:16982773-Laryngeal Neoplasms,
pubmed-meshheading:16982773-Male,
pubmed-meshheading:16982773-Middle Aged,
pubmed-meshheading:16982773-Neoplasm Staging,
pubmed-meshheading:16982773-Prognosis,
pubmed-meshheading:16982773-Tumor Markers, Biological
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| pubmed:year |
2006
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| pubmed:articleTitle |
HLA class I antigen down-regulation in primary laryngeal squamous cell carcinoma lesions as a poor prognostic marker.
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| pubmed:affiliation |
Department of Otolaryngology-Head and Neck Surgery, Division of Surgical Pathology, Asahikawa Medical College Hospital, Asahikawa, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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