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The present study investigated the sealing ability of four root canal sealers at two different thicknesses. There were 82 maxillary incisors roots prepared with Gates Glidden drills up to size 6 and divided into four groups: Pulp Canal Sealer, EndoREZ, Sealapex, and AH Plus. Each group was divided in two subgroups and gutta-percha cylinders 1.5 or 1 mm wide were used, respectively. The roots were mounted in a bacterial leakage model and the system was checked daily during the following 12 wk. Data were analyzed by Log-Rank test and Student t-test. In the thin layer samples, the sealers demonstrated similar results while, in the thick layer samples, AH Plus revealed the best performance. Generally, greater sealer thickness influenced negatively the sealing ability of the root canal filling, except in AH Plus samples.
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