Source:http://linkedlifedata.com/resource/pubmed/id/16980947
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2006-11-22
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| pubmed:abstractText |
It remains unclear whether or not diffuse large B-cell lymphomas of extranodal sites arise from mucosa-associated lymphoid tissue (MALT) lymphomas. We studied the clinicopathological features of MALT lymphoma and diffuse large B-cell lymphoma in the thyroid gland, with special reference to VH usage of immunoglobulin gene rearrangement, to clarify the relationships between these two types of lymphomas. In addition, t(11; 18) (q21; q21) translocation was examined by multiplex reverse transcription-polymerase chain reaction. We examined 58 patients with primary thyroid lymphoma: 31 (male seven and female 24) with MALT lymphoma and 27 (male three and female 24) with diffuse large B-cell lymphoma. Interestingly, the sequence of VH genes revealed that the two subtypes differed significantly in their use of the VH4 family (P < 0.05). Of the seven MALT lymphomas, three used the VH4 family and the other four used the VH3 family, whereas eight out of nine diffuse large B-cell lymphoma used the VH3 family, one used the VH1 family, and none used the VH4 family. It was also interesting that, in one diffuse large B-cell lymphoma patient with MALT lymphoma, the diffuse large B-cell lymphoma component used the VH3 family and the MALT lymphoma component used the VH4 family. These data imply that, in a subset of cases, these two subtypes do not share a common origin and that at least some diffuse large B-cell lymphomas have a de novo origin. No t(11; 18) (q21; q21) was detected in thyroid lymphomas, which are different from MALT lymphoma of the stomach, lungs, large intestine and ocular adnexa. This strongly indicated that the presence of t(11; 18) (q21; q21) in MALT lymphoma is organ-specific.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0893-3952
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
19
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1578-84
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16980947-Adult,
pubmed-meshheading:16980947-Aged,
pubmed-meshheading:16980947-Aged, 80 and over,
pubmed-meshheading:16980947-Chromosomes, Human, Pair 11,
pubmed-meshheading:16980947-Chromosomes, Human, Pair 18,
pubmed-meshheading:16980947-Female,
pubmed-meshheading:16980947-Gene Rearrangement, B-Lymphocyte,
pubmed-meshheading:16980947-Genes, Immunoglobulin,
pubmed-meshheading:16980947-Humans,
pubmed-meshheading:16980947-Immunoenzyme Techniques,
pubmed-meshheading:16980947-Immunoglobulin Variable Region,
pubmed-meshheading:16980947-Lymphoma, B-Cell,
pubmed-meshheading:16980947-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:16980947-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:16980947-Male,
pubmed-meshheading:16980947-Middle Aged,
pubmed-meshheading:16980947-Neoplasm Staging,
pubmed-meshheading:16980947-Organ Specificity,
pubmed-meshheading:16980947-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16980947-Thyroid Neoplasms,
pubmed-meshheading:16980947-Translocation, Genetic
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| pubmed:year |
2006
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| pubmed:articleTitle |
Deviated VH4 immunoglobulin gene usage is found among thyroid mucosa-associated lymphoid tissue lymphomas, similar to the usage at other sites, but is not found in thyroid diffuse large B-cell lymphomas.
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| pubmed:affiliation |
Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
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| pubmed:publicationType |
Journal Article
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