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pubmed-article:16979810pubmed:abstractTextMethacrylic compounds such as 2-hydroxyethyl methacrylate (HEMA), triethylene glycol dimethacrylate (TEGDMA) and bisphenol A glycerolate (1 glycerol/phenol) dimethacrylate (Bis-GMA) are largely present in auto- or photopolymerizable composite resins. Since the polymerization reaction is never complete, these molecules are released into the oral cavity tissues and biological fluids where they could cause local adverse effects. The aim of this work was to verify the hypothesis that the biological effects of HEMA, TEGDMA and Bis-GMA - at a non-cytotoxic concentration - depend on the interaction with mitochondria and exert consequent alterations of energy metabolism, GSH levels and the related pathways in human promyelocytic cell line (HL-60).lld:pubmed
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pubmed-article:16979810pubmed:articleTitleAlterations of energy metabolism and glutathione levels of HL-60 cells induced by methacrylates present in composite resins.lld:pubmed
pubmed-article:16979810pubmed:affiliationBiochemistry and Clinical Biochemistry Institute, School of Medicine, Catholic University, Rome, Italy. g.nocca@rm.unicatt.itlld:pubmed
pubmed-article:16979810pubmed:publicationTypeJournal Articlelld:pubmed