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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-2-6
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pubmed:abstractText |
Methacrylic compounds such as 2-hydroxyethyl methacrylate (HEMA), triethylene glycol dimethacrylate (TEGDMA) and bisphenol A glycerolate (1 glycerol/phenol) dimethacrylate (Bis-GMA) are largely present in auto- or photopolymerizable composite resins. Since the polymerization reaction is never complete, these molecules are released into the oral cavity tissues and biological fluids where they could cause local adverse effects. The aim of this work was to verify the hypothesis that the biological effects of HEMA, TEGDMA and Bis-GMA - at a non-cytotoxic concentration - depend on the interaction with mitochondria and exert consequent alterations of energy metabolism, GSH levels and the related pathways in human promyelocytic cell line (HL-60).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bisphenol A-Glycidyl Methacrylate,
http://linkedlifedata.com/resource/pubmed/chemical/Composite Resins,
http://linkedlifedata.com/resource/pubmed/chemical/Dental Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosephosphate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Methacrylates,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Polymethacrylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/hydroxyethyl methacrylate,
http://linkedlifedata.com/resource/pubmed/chemical/triethylene glycol dimethacrylate
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0300-5712
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pubmed:author |
pubmed-author:CallàCC,
pubmed-author:ChimentiCC,
pubmed-author:De PalmaFF,
pubmed-author:De SolePP,
pubmed-author:GambariniGG,
pubmed-author:GiardinaBB,
pubmed-author:GozzoM LML,
pubmed-author:LupiAA,
pubmed-author:MartoranaG EGE,
pubmed-author:MinucciAA,
pubmed-author:MorlacchiCC,
pubmed-author:NoccaGG
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-94
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pubmed:meshHeading |
pubmed-meshheading:16979810-Bisphenol A-Glycidyl Methacrylate,
pubmed-meshheading:16979810-Cell Differentiation,
pubmed-meshheading:16979810-Cell Proliferation,
pubmed-meshheading:16979810-Cell Survival,
pubmed-meshheading:16979810-Composite Resins,
pubmed-meshheading:16979810-Dental Materials,
pubmed-meshheading:16979810-Energy Metabolism,
pubmed-meshheading:16979810-Glucose,
pubmed-meshheading:16979810-Glucosephosphate Dehydrogenase,
pubmed-meshheading:16979810-Glutathione,
pubmed-meshheading:16979810-Glutathione Reductase,
pubmed-meshheading:16979810-HL-60 Cells,
pubmed-meshheading:16979810-Humans,
pubmed-meshheading:16979810-Lactic Acid,
pubmed-meshheading:16979810-Methacrylates,
pubmed-meshheading:16979810-Mitochondria,
pubmed-meshheading:16979810-Oxygen Consumption,
pubmed-meshheading:16979810-Polyethylene Glycols,
pubmed-meshheading:16979810-Polymers,
pubmed-meshheading:16979810-Polymethacrylic Acids
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pubmed:year |
2007
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pubmed:articleTitle |
Alterations of energy metabolism and glutathione levels of HL-60 cells induced by methacrylates present in composite resins.
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pubmed:affiliation |
Biochemistry and Clinical Biochemistry Institute, School of Medicine, Catholic University, Rome, Italy. g.nocca@rm.unicatt.it
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pubmed:publicationType |
Journal Article
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