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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2006-9-26
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pubmed:abstractText |
Isoprenylation of geranylgeranyl-pyrophosphate (GGPP) is critical for activation of small GTPases. We examined the roles of GGPP synthase (GGPPS) during the differentiation induced by the cell-to-cell contact in osteoblastic cell line MC3T3-E1 cells. We found that (1) both mRNA and protein expression of GGPPS was reduced with decrement of its activity during the differentiation, (2) GGOH, which is converted to GGPP in the cells, inhibited differentiation. These results suggest that the decrement of GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
pubmed-author:AsanumaMieM,
pubmed-author:FuseMasamiM,
pubmed-author:GrossmannLauraL,
pubmed-author:SaitoYasushiY,
pubmed-author:ShibataTakahisaT,
pubmed-author:TanakaTomoakiT,
pubmed-author:TatsunoIchiroI,
pubmed-author:UenoKoichiK,
pubmed-author:YasudaTatsujiT,
pubmed-author:YonekawaTaekoT,
pubmed-author:YoshidaTomohikoT
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
580
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5203-7
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pubmed:meshHeading |
pubmed-meshheading:16978613-Animals,
pubmed-meshheading:16978613-Cell Communication,
pubmed-meshheading:16978613-Cell Differentiation,
pubmed-meshheading:16978613-Cell Line,
pubmed-meshheading:16978613-Down-Regulation,
pubmed-meshheading:16978613-Enzyme Activation,
pubmed-meshheading:16978613-Farnesyltranstransferase,
pubmed-meshheading:16978613-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:16978613-Mice,
pubmed-meshheading:16978613-Monomeric GTP-Binding Proteins,
pubmed-meshheading:16978613-Multienzyme Complexes,
pubmed-meshheading:16978613-Osteoblasts,
pubmed-meshheading:16978613-RNA, Messenger
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pubmed:year |
2006
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pubmed:articleTitle |
Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1.
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pubmed:affiliation |
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chiba-city, Chiba 260-8670, Japan.
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pubmed:publicationType |
Journal Article
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