rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
2006-10-11
|
pubmed:abstractText |
The influence of Exisulind on the viability and apoptosis of CD34(+) stem cells from patients with advanced myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML)/MDS was investigated. In eight out of 10 patient samples Exisulind reduced the fraction of viable cells by inducing apoptosis. We found evidence that Exisulind-mediated apoptosis depends on c-Jun NH(2)-terminal kinase (JNK) activation. Addition of a specific JNK-inhibitor to Exisulind-treated advanced MDS and AML/MDS cells partly abrogated apoptosis. We propose that Exisulind is tested in clinical phase I/II trials for the treatment of advanced MDS and AML/MDS.
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0007-1048
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
135
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
355-7
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:16978222-Acute Disease,
pubmed-meshheading:16978222-Antigens, CD34,
pubmed-meshheading:16978222-Antineoplastic Agents,
pubmed-meshheading:16978222-Apoptosis,
pubmed-meshheading:16978222-Cell Survival,
pubmed-meshheading:16978222-Cells, Cultured,
pubmed-meshheading:16978222-Enzyme Activation,
pubmed-meshheading:16978222-Humans,
pubmed-meshheading:16978222-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:16978222-Leukemia, Myeloid,
pubmed-meshheading:16978222-Myelodysplastic Syndromes,
pubmed-meshheading:16978222-Stem Cells,
pubmed-meshheading:16978222-Sulindac
|
pubmed:year |
2006
|
pubmed:articleTitle |
Exisulind induces apoptosis in advanced myelodysplastic syndrome (MDS) and acute myeloid leukaemia/MDS.
|
pubmed:affiliation |
Department of Haematology, Oncology and Clinical Immunology, Heinrich Heine-University, Düsseldorf, Germany. aczibere@bidmc.harvard.edu
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|