Source:http://linkedlifedata.com/resource/pubmed/id/16977260
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2006-9-15
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pubmed:abstractText |
Granulocytes from healthy subjects and from patients suffering from diabetes mellitus present differences in reactivity to stimulation with cyclic nucleotide-elevating agents. The production of reactive oxygen species (ROS) is inhibited in cells from non-diabetic subjects following such stimulation, but activated through a PKA-independent signaling pathway in granulocytes from type 1 and type 2 diabetic patients. The aim of the present study was to understand better the changes in signaling mechanisms induced by the disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1262-3636
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
331-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16977260-Adult,
pubmed-meshheading:16977260-Bucladesine,
pubmed-meshheading:16977260-Cyclic AMP,
pubmed-meshheading:16977260-Diabetes Mellitus, Type 1,
pubmed-meshheading:16977260-Diabetes Mellitus, Type 2,
pubmed-meshheading:16977260-Female,
pubmed-meshheading:16977260-Granulocytes,
pubmed-meshheading:16977260-Humans,
pubmed-meshheading:16977260-Male,
pubmed-meshheading:16977260-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:16977260-Reactive Oxygen Species,
pubmed-meshheading:16977260-Reference Values
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pubmed:year |
2006
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pubmed:articleTitle |
Modulation of the production of reactive oxygen species (ROS) by cAMP-elevating agents in granulocytes from diabetic patients: an Akt/PKB-dependent phenomenon.
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pubmed:affiliation |
Hospital Santa Casa de Belo Horizonte, Núcleo de Pesquisa e Pós, Graduação (NPPG), Brasil. nogueira.machado@pesquisador.cnpq.br
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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