| pubmed-article:1697660 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1697660 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:1697660 | lifeskim:mentions | umls-concept:C0034261 | lld:lifeskim |
| pubmed-article:1697660 | lifeskim:mentions | umls-concept:C1154417 | lld:lifeskim |
| pubmed-article:1697660 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1697660 | pubmed:dateCreated | 1990-10-10 | lld:pubmed |
| pubmed-article:1697660 | pubmed:abstractText | The coadministration of growth hormone (GH) secretagogues can provide insight into the neuroregulation of GH secretion. The GH response to L-dopa (125, 250 and 500 mg orally for body weights less than 15 kg, between 15 and 30 kg and greater than 30 kg, respectively), arginine (Arg; 0.5 g/kg infused intravenously over 30 min) and galanin (GAL; 15 micrograms/kg infused intravenously over 60 min) when administered alone or combined with pyridostigmine (PD; 60 mg orally), a cholinergic agonist that likely acts via inhibition of endogenous somatostatin secretion, was studied in children with familial short stature. The GH-releasing effect of PD was also evaluated. In 8 children, PD and L-dopa when administered alone induced an equivalent GH rise (area under the response curve, mean +/- SEM: 241.4 +/- 31.1 vs. 202.9 +/- 38.6 micrograms/l/h) while their coadministration had an additive effect (435.4 +/- 41.4 micrograms/l/h; p less than 0.02 vs. PD and L-dopa alone). On the contrary, in other 8 children, PD and Arg induced similar GH increases either when administered alone (394.2 +/- 68.5 vs. 405.8 +/- 103.9 micrograms/l/h) or in combination (535.8 +/- 97.3 micrograms/l/h). GH increases almost superimposable were also observed when PD and GAL were administered alone (405.2 +/- 72.3 vs. 412.6 +/- 94.1 micrograms/l/h) or in combination (537.9 +/- 139.0 micrograms/l/h) in other 7 children. These data show that the enhancement of the cholinergic activity by PD increases the L-dopa-induced GH release but fails to modify both Arg- and GAL-induced GH release in short children.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1697660 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1697660 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1697660 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1697660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1697660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1697660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1697660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1697660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1697660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1697660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1697660 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1697660 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1697660 | pubmed:issn | 0028-3835 | lld:pubmed |
| pubmed-article:1697660 | pubmed:author | pubmed-author:GhigoEE | lld:pubmed |
| pubmed-article:1697660 | pubmed:author | pubmed-author:De SanctisCC | lld:pubmed |
| pubmed-article:1697660 | pubmed:author | pubmed-author:MazzaEE | lld:pubmed |
| pubmed-article:1697660 | pubmed:author | pubmed-author:LocheSS | lld:pubmed |
| pubmed-article:1697660 | pubmed:author | pubmed-author:ArvatEE | lld:pubmed |
| pubmed-article:1697660 | pubmed:author | pubmed-author:CappaMM | lld:pubmed |
| pubmed-article:1697660 | pubmed:author | pubmed-author:ValettoM RMR | lld:pubmed |
| pubmed-article:1697660 | pubmed:author | pubmed-author:BelloneJJ | lld:pubmed |
| pubmed-article:1697660 | pubmed:author | pubmed-author:BoffanoG MGM | lld:pubmed |
| pubmed-article:1697660 | pubmed:author | pubmed-author:ImperialeEE | lld:pubmed |
| pubmed-article:1697660 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1697660 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:1697660 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1697660 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:1697660 | pubmed:pagination | 42-5 | lld:pubmed |
| pubmed-article:1697660 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1697660 | pubmed:meshHeading | pubmed-meshheading:1697660-... | lld:pubmed |
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| pubmed-article:1697660 | pubmed:meshHeading | pubmed-meshheading:1697660-... | lld:pubmed |
| pubmed-article:1697660 | pubmed:meshHeading | pubmed-meshheading:1697660-... | lld:pubmed |
| pubmed-article:1697660 | pubmed:meshHeading | pubmed-meshheading:1697660-... | lld:pubmed |
| pubmed-article:1697660 | pubmed:meshHeading | pubmed-meshheading:1697660-... | lld:pubmed |
| pubmed-article:1697660 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1697660 | pubmed:articleTitle | Pyridostigmine potentiates L-dopa- but not arginine- and galanin-induced growth hormone secretion in children. | lld:pubmed |
| pubmed-article:1697660 | pubmed:affiliation | Department of Clinical Physiopathology, University of Turin, Italy. | lld:pubmed |
| pubmed-article:1697660 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1697660 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
