Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-10-11
pubmed:abstractText
Bovine herpes virus type 1 (BHV-1) gIII is a major virion glycoprotein with homology to the immunoglobulin superfamily. We have investigated the possibility that gIII is related to host molecules and have identified a gIII-specific monoclonal antibody (mAb) that cross-reacts with normal bovine cells. The cross-reactive entity was expressed mainly on monocyte/macrophages (M phi), polymorphonuclear leucocytes (PMN) and platelets, and was identified as a 43,000-63,000 molecular weight (MW) cell-surface glycoprotein. For M phi, the glycoprotein appears to be a general lineage marker, rather than a maturation or activation marker, and may be a functional receptor, as evidenced by its endocytosis via coated pits and its involvement in proliferation of mononuclear cells in vitro. This novel leucocyte marker was also detected on subsets of human, ovine and canine M phi. Competitive binding assays with sera from cattle immunized with BHV-1 or gIII revealed apparent low responsiveness to the cross-reactive epitope. The results suggest that BHV-1 gIII is antigenically related to a novel host leucocyte receptor and that evasion and/or interference with leucocyte function may be a consequence of this molecular mimicry relationship.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-1691884, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2155290, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2414916, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2420063, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2426466, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2446012, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2461006, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2464439, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2476147, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2516741, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2553336, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2580916, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2803503, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-2845135, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-3001213, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-3048251, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-3114940, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-3139783, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-3148270, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-3280679, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-3465828, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-3805742, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-6275094, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-6279511, http://linkedlifedata.com/resource/pubmed/commentcorrection/1697564-6377683
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
504-12
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Molecular mimicry: a herpes virus glycoprotein antigenically related to a cell-surface glycoprotein expressed by macrophages, polymorphonuclear leucocytes, and platelets.
pubmed:affiliation
Veterinary Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't