Linked Life Data

1697482

Source:http://linkedlifedata.com/resource/pubmed/id/1697482

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-10-10
pubmed:abstractText
In order to demonstrate the participation of galactose-containing carbohydrate epitopes on the surface of model IgG complexes (MIC) during their interaction with high molecular weight ligands, MIC were obtained. The interaction of MIC with Ricinus communis agglutinin (RCA) was studied. The time-dependent changes in the intensity of light scattering in solutions containing MIC of different molecular masses were measured after addition of RCA. It was shown that the efficiency of MIC interaction with RCA depends on the molecular mass of the former. The binding of RCA to MIC is highly specific, it being completely abolished after addition of lactose (1-15 mM). It was found that the final lactose concentration necessary for the complete inhibition of MIC interaction with RCA to take place, depends on the molecular mass of MIC. The data obtained point to the accessibility of IgG oligosaccharide antennae within the composition of MIC for the binding to high molecular weight ligands as well as to the increased density of galactose-containing epitopes on the surface of MIC resulting from the increase in their molecular mass.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0320-9725
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
856-64
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Interaction of model IgG complexes with lectin from Ricinus communis in solutions studied by light scattering method].
pubmed:publicationType
Journal Article, English Abstract