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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-11-19
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pubmed:abstractText |
Permeability of blood vessels is essential for tissue homeostasis. However, disorganized hyperpermeability leads to progression of diseases. Vascular endothelial growth factor-A (VEGF) is a key regulator for leakiness of blood vessels and it has been reported that VEGF-mediated hyperpermeability was suppressed by angiopoietin-1 (Ang1). We found that Angiotensin-converting enzyme (ACE) was downregulated in endothelial cells by Ang1. ACE converts angiotensin I to angiotensin II (AII). Here, we studied the relationship between VEGF and AII relative to vascular permeability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/cadherin 5,
http://linkedlifedata.com/resource/pubmed/chemical/vascular endothelial growth factor...,
http://linkedlifedata.com/resource/pubmed/chemical/zonula occludens-1 protein
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2673-80
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16973968-Angioedema,
pubmed-meshheading:16973968-Angiopoietin-1,
pubmed-meshheading:16973968-Angiotensin II,
pubmed-meshheading:16973968-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:16973968-Animals,
pubmed-meshheading:16973968-Antigens, CD,
pubmed-meshheading:16973968-Cadherins,
pubmed-meshheading:16973968-Capillary Permeability,
pubmed-meshheading:16973968-Cell Membrane Permeability,
pubmed-meshheading:16973968-Cells, Cultured,
pubmed-meshheading:16973968-Down-Regulation,
pubmed-meshheading:16973968-Endothelium, Vascular,
pubmed-meshheading:16973968-Gene Expression Regulation,
pubmed-meshheading:16973968-Humans,
pubmed-meshheading:16973968-Membrane Proteins,
pubmed-meshheading:16973968-Mice,
pubmed-meshheading:16973968-Mice, Inbred C57BL,
pubmed-meshheading:16973968-Mice, Inbred ICR,
pubmed-meshheading:16973968-Mice, Knockout,
pubmed-meshheading:16973968-Peptidyl-Dipeptidase A,
pubmed-meshheading:16973968-Phosphoproteins,
pubmed-meshheading:16973968-RNA, Messenger,
pubmed-meshheading:16973968-Receptor, Angiotensin, Type 1,
pubmed-meshheading:16973968-Vascular Endothelial Growth Factor A
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pubmed:year |
2006
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pubmed:articleTitle |
Negative regulation of VEGF-induced vascular leakage by blockade of angiotensin II type 1 receptor.
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pubmed:affiliation |
Department of Stem Cell Biology, Cancer Research Institute, Kanazawa University, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-0934 Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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