Source:http://linkedlifedata.com/resource/pubmed/id/16973360
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
2006-11-10
|
| pubmed:abstractText |
Structure-activity relationships for a recently discovered thiazolyl phenyl ether series of acetyl-CoA carboxylase (ACC) inhibitors were investigated. Preliminary efforts to optimize the series through modification of the distal aryl ether moiety of the lead scaffold resulted in the identification of compounds exhibiting low-nanomolar potency and isozyme-selective ACC2 activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
|
| pubmed:author |
pubmed-author:BeutelBruce ABA,
pubmed-author:CampHeidi SHS,
pubmed-author:ClarkRichard FRF,
pubmed-author:FrevertErnst UEU,
pubmed-author:GuYu GuiYG,
pubmed-author:HansenT MatthewTM,
pubmed-author:LiuGangG,
pubmed-author:ShamHing LHL,
pubmed-author:WangRongqiR,
pubmed-author:WangXiaojunX,
pubmed-author:WangYingY,
pubmed-author:XinZhiliZ,
pubmed-author:ZhangTianyuanT,
pubmed-author:ZhangXiaolinX
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6078-81
|
| pubmed:meshHeading | |
| pubmed:year |
2006
|
| pubmed:articleTitle |
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
|
| pubmed:affiliation |
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. rick.clark@abbott.com <rick.clark@abbott.com>
|
| pubmed:publicationType |
Journal Article
|