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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-10-18
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pubmed:abstractText |
We aimed to investigate the effect of subchronic administration of dichlorvos (DDVP) on endometrium and to evaluate ameliorating effects of a combination of Vitamins E and C against DDVP toxicity in the rat. Three groups of rats were used in the experiment. The first group was treated with 4 mg/kg DDVP; the second group was treated with 4 mg/kg body weight DDVP plus Vitamins E and C (DDVP+Vit); the third group was given only corn oil (control). DDVP and DDVP+Vit groups were given DDVP by gavage 5 days a week for 4 weeks at a dose level of 4 mg/kg day by using corn oil as the vechicle. Vitamins E and C were injected at doses of 50 mg/kg i.m. and 20 mg/kg body weight i.p. Histopathological and immunohistochemical examinations for caspase-3 and caspase-9 were accomplished in the endometrium. The level of malondialdehyde (MDA) increased significantly in the DDVP group compared with the control group (p<0.05). MDA significantly decreased in the DDVP+Vit group compared with the DDVP group (p<0.05). Administration of Vitamins E and C along with DDVP significantly reduced the histopathological changes and the extent of apoptosis. In conclusion, subchronic DDVP administration caused endometrial damage and that treatment with a combination of Vitamins E and C reduced endometrial damage caused by DDVP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0890-6238
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
783-90
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pubmed:meshHeading |
pubmed-meshheading:16973328-Animals,
pubmed-meshheading:16973328-Antioxidants,
pubmed-meshheading:16973328-Apoptosis,
pubmed-meshheading:16973328-Ascorbic Acid,
pubmed-meshheading:16973328-Caspase 3,
pubmed-meshheading:16973328-Caspase 9,
pubmed-meshheading:16973328-Cholinesterase Inhibitors,
pubmed-meshheading:16973328-Cholinesterases,
pubmed-meshheading:16973328-Dichlorvos,
pubmed-meshheading:16973328-Diestrus,
pubmed-meshheading:16973328-Endometrium,
pubmed-meshheading:16973328-Estrus,
pubmed-meshheading:16973328-Fasciculation,
pubmed-meshheading:16973328-Female,
pubmed-meshheading:16973328-Immunohistochemistry,
pubmed-meshheading:16973328-Injections, Intramuscular,
pubmed-meshheading:16973328-Intubation, Gastrointestinal,
pubmed-meshheading:16973328-Lipid Peroxidation,
pubmed-meshheading:16973328-Malondialdehyde,
pubmed-meshheading:16973328-Organophosphorus Compounds,
pubmed-meshheading:16973328-Rats,
pubmed-meshheading:16973328-Rats, Wistar,
pubmed-meshheading:16973328-Vitamin E,
pubmed-meshheading:16973328-Weight Gain
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pubmed:year |
2006
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pubmed:articleTitle |
Endometrial damage and apoptosis in rats induced by dichlorvos and ameliorating effect of antioxidant vitamins E and C.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
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pubmed:publicationType |
Journal Article
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