| pubmed-article:16970918 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16970918 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:16970918 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:16970918 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:16970918 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16970918 | lifeskim:mentions | umls-concept:C0872252 | lld:lifeskim |
| pubmed-article:16970918 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16970918 | lifeskim:mentions | umls-concept:C1121519 | lld:lifeskim |
| pubmed-article:16970918 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16970918 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16970918 | pubmed:dateCreated | 2006-9-22 | lld:pubmed |
| pubmed-article:16970918 | pubmed:abstractText | PRIMA-1 has emerged as a small molecule that restores the wild type function to mutant p53. To identify molecular targets that are involved in PRIMA-1-induced apoptosis, we used a proteomics approach with two-dimensional gel electrophoresis coupled with liquid chromatography-tandem mass spectrometry for protein identification. By comparing the proteome of the PRIMA-1-treated MDA-231 breast carcinoma cells with that of MCF-7 cells, we have identified seven proteins that upregulated only in MDA-231 cells as a result of PRIMA-1-induced apoptosis. The identified proteins are involved in anaerobic glycolysis and in mitochondrial intrinsic apoptosis. Treatment of MDA-231 cells with PRIMA-1 resulted in the release of mitochondrial cytochrome c as well as the activation of caspase-3, which are essential for the execution of apoptosis. We present evidence to suggest that PRIMA-1-induced apoptosis in breast cancer cells with mutated p53 function involved the expression of proteins required for the activation of mitochondrial intrinsic pathway that is glycolysis-relevant. | lld:pubmed |
| pubmed-article:16970918 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16970918 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16970918 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16970918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16970918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16970918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16970918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16970918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16970918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16970918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16970918 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16970918 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16970918 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16970918 | pubmed:author | pubmed-author:LeeKyungheeK | lld:pubmed |
| pubmed-article:16970918 | pubmed:author | pubmed-author:WangTaoT | lld:pubmed |
| pubmed-article:16970918 | pubmed:author | pubmed-author:DaoudSayed... | lld:pubmed |
| pubmed-article:16970918 | pubmed:author | pubmed-author:PaszczynskiAn... | lld:pubmed |
| pubmed-article:16970918 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16970918 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:16970918 | pubmed:volume | 349 | lld:pubmed |
| pubmed-article:16970918 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16970918 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16970918 | pubmed:pagination | 1117-24 | lld:pubmed |
| pubmed-article:16970918 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:meshHeading | pubmed-meshheading:16970918... | lld:pubmed |
| pubmed-article:16970918 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16970918 | pubmed:articleTitle | Expression proteomics to p53 mutation reactivation with PRIMA-1 in breast cancer cells. | lld:pubmed |
| pubmed-article:16970918 | pubmed:affiliation | Department of Pharmaceutical Sciences, Washington State University, 259 Wegner Hall, Pullman, WA 99164-6534, USA. | lld:pubmed |
| pubmed-article:16970918 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16970918 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
