|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2006-12-20
|
|
pubmed:abstractText |
We compared early- with late-onset cases in 86 patients with familial amyloidotic polyneuropathy type I (FAP). Among these patients, 43 presented before age 50 (early-onset) and 43 after this age (late-onset). Sex and geographical distribution were similar, although a family history of the disorder was more frequent in early-onset cases. In late-onset disease, autonomic dysfunction was less frequent, but organ involvement and severe neuropathic pain were more frequent. Neurophysiological measurements were similar. FAP is a cause of neuropathy in elderly patients, in particular in those presenting with neuropathic pain.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0148-639X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
35
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
116-8
|
|
pubmed:meshHeading |
pubmed-meshheading:16969832-Adult,
pubmed-meshheading:16969832-Age of Onset,
pubmed-meshheading:16969832-Amino Acid Sequence,
pubmed-meshheading:16969832-Amino Acid Substitution,
pubmed-meshheading:16969832-Amyloid Neuropathies, Familial,
pubmed-meshheading:16969832-Autonomic Nervous System Diseases,
pubmed-meshheading:16969832-Female,
pubmed-meshheading:16969832-Genetic Predisposition to Disease,
pubmed-meshheading:16969832-Geography,
pubmed-meshheading:16969832-Humans,
pubmed-meshheading:16969832-Inheritance Patterns,
pubmed-meshheading:16969832-Longitudinal Studies,
pubmed-meshheading:16969832-Male,
pubmed-meshheading:16969832-Methionine,
pubmed-meshheading:16969832-Middle Aged,
pubmed-meshheading:16969832-Mutation,
pubmed-meshheading:16969832-Neuralgia,
pubmed-meshheading:16969832-Peripheral Nervous System Diseases,
pubmed-meshheading:16969832-Portugal,
pubmed-meshheading:16969832-Prospective Studies,
pubmed-meshheading:16969832-Sex Distribution,
pubmed-meshheading:16969832-Valine
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Clinical variability in type I familial amyloid polyneuropathy (Val30Met): comparison between late- and early-onset cases in Portugal.
|
|
pubmed:affiliation |
Department of Neurology and Neuromuscular Unit, Institute of Molecular Medicine, Faculty of Medicine, Hospital de Santa Maria, Av Prof Egas Moniz, 1649-028, Lisbon, Portugal.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
