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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1990-9-27
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pubmed:abstractText |
A monoclonal antibody (mAb) directed against a synthetic peptide derived from the sequence of the human immunodeficiency virus type 1 (HIV-1) regulatory protein virion infectivity factor (vif) labeled the surface of Schistosoma mansoni schistosomula by indirect immunofluorescence. Western blotting showed that two S. mansoni proteins of 170 and 65 kD were recognized by the mAb. Sera from 20% of S. mansoni-infected HIV-seronegative individuals tested recognized the PS4 peptide in an ELISA as did sera from S. mansoni-infected rats. Sera from individuals seropositive for HIV-1, but without schistosomiasis, that reacted with the vif peptide also recognized a 170-kD S. mansoni protein. This crossreactive S. mansoni antigen appears to be a target of immunity in vivo since passive transfer of the mAb VIF-CD3 to naive rats had a protective effect against a challenge infection with S. mansoni cercariae.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-2430044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-2723436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-2786420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-2863543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-2989191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-3006244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-3118220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-3142117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-3163253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-4035741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-4631607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-4957633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-6710563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696953-7142705
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Helminth,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, vif,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Regulatory and Accessory...,
http://linkedlifedata.com/resource/pubmed/chemical/vif Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1001-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1696953-Amino Acid Sequence,
pubmed-meshheading:1696953-Animals,
pubmed-meshheading:1696953-Antibodies, Monoclonal,
pubmed-meshheading:1696953-Antigens, Helminth,
pubmed-meshheading:1696953-Antigens, Surface,
pubmed-meshheading:1696953-Child,
pubmed-meshheading:1696953-Cross Reactions,
pubmed-meshheading:1696953-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1696953-Epitopes,
pubmed-meshheading:1696953-Fluorescent Antibody Technique,
pubmed-meshheading:1696953-Gene Products, vif,
pubmed-meshheading:1696953-HIV Seropositivity,
pubmed-meshheading:1696953-HIV-1,
pubmed-meshheading:1696953-Humans,
pubmed-meshheading:1696953-Molecular Sequence Data,
pubmed-meshheading:1696953-Peptides,
pubmed-meshheading:1696953-Rats,
pubmed-meshheading:1696953-Rats, Inbred Strains,
pubmed-meshheading:1696953-Schistosoma mansoni,
pubmed-meshheading:1696953-Schistosomiasis mansoni,
pubmed-meshheading:1696953-Viral Regulatory and Accessory Proteins,
pubmed-meshheading:1696953-Virion,
pubmed-meshheading:1696953-vif Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1990
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pubmed:articleTitle |
Immunological crossreactivity between the human immunodeficiency virus type 1 virion infectivity factor and a 170-kD surface antigen of Schistosoma mansoni.
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pubmed:affiliation |
Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM, U167-CNRS 624, Strasbourg, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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