Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-1-17
pubmed:abstractText
Serine protease inhibitor member 3 of clade A (SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G. The release of neutrophil cathepsin G (proteolytic enzyme) can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders. In a previous report there was evidence that an alanine/threonine polymorphism was associated with the risk factor for aneurysmal subarachnoid hemorrhage (SAH) in a Polish population. We performed this study to determine whether this A15T polymorphism shows the same association in a Japanese population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1015-9770
pubmed:author
pubmed:copyrightInfo
Copyright 2007 S. Karger AG, Basel.
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
46-9
pubmed:dateRevised
2007-4-18
pubmed:meshHeading
pubmed-meshheading:16968986-Alanine, pubmed-meshheading:16968986-Aneurysm, Ruptured, pubmed-meshheading:16968986-Asian Continental Ancestry Group, pubmed-meshheading:16968986-Case-Control Studies, pubmed-meshheading:16968986-Female, pubmed-meshheading:16968986-Gene Frequency, pubmed-meshheading:16968986-Genetic Predisposition to Disease, pubmed-meshheading:16968986-Genotype, pubmed-meshheading:16968986-Humans, pubmed-meshheading:16968986-Intracranial Aneurysm, pubmed-meshheading:16968986-Japan, pubmed-meshheading:16968986-Male, pubmed-meshheading:16968986-Middle Aged, pubmed-meshheading:16968986-Polymorphism, Single Nucleotide, pubmed-meshheading:16968986-Risk Factors, pubmed-meshheading:16968986-Serpins, pubmed-meshheading:16968986-Subarachnoid Hemorrhage, pubmed-meshheading:16968986-Threonine
pubmed:year
2007
pubmed:articleTitle
The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population.
pubmed:affiliation
Division of Genetic Diagnosis, Institute of Medical Science, University of Tokyo, Tokyo, Japan. boris@krischek.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't