rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-17
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pubmed:abstractText |
Serine protease inhibitor member 3 of clade A (SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G. The release of neutrophil cathepsin G (proteolytic enzyme) can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders. In a previous report there was evidence that an alanine/threonine polymorphism was associated with the risk factor for aneurysmal subarachnoid hemorrhage (SAH) in a Polish population. We performed this study to determine whether this A15T polymorphism shows the same association in a Japanese population.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1015-9770
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2007 S. Karger AG, Basel.
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
46-9
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pubmed:dateRevised |
2007-4-18
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pubmed:meshHeading |
pubmed-meshheading:16968986-Alanine,
pubmed-meshheading:16968986-Aneurysm, Ruptured,
pubmed-meshheading:16968986-Asian Continental Ancestry Group,
pubmed-meshheading:16968986-Case-Control Studies,
pubmed-meshheading:16968986-Female,
pubmed-meshheading:16968986-Gene Frequency,
pubmed-meshheading:16968986-Genetic Predisposition to Disease,
pubmed-meshheading:16968986-Genotype,
pubmed-meshheading:16968986-Humans,
pubmed-meshheading:16968986-Intracranial Aneurysm,
pubmed-meshheading:16968986-Japan,
pubmed-meshheading:16968986-Male,
pubmed-meshheading:16968986-Middle Aged,
pubmed-meshheading:16968986-Polymorphism, Single Nucleotide,
pubmed-meshheading:16968986-Risk Factors,
pubmed-meshheading:16968986-Serpins,
pubmed-meshheading:16968986-Subarachnoid Hemorrhage,
pubmed-meshheading:16968986-Threonine
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pubmed:year |
2007
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pubmed:articleTitle |
The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population.
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pubmed:affiliation |
Division of Genetic Diagnosis, Institute of Medical Science, University of Tokyo, Tokyo, Japan. boris@krischek.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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