Linked Life Data

16968868

Source:http://linkedlifedata.com/resource/pubmed/id/16968868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-6-11
pubmed:abstractText
In proactive interference (PI) paradigms, previous learning impairs the acquisition of new, related information. In rats, efficient resolution of PI relies on cholinergic modulation from the basal forebrain (BF). To test whether humans resolve PI using a functional network dependent on the medial septum/diagonal band of Broca (MS/DB) nuclei of the BF, we analyzed functional magnetic resonance imaging signal recorded while human participants learned to respond to baseline color paired associates and then additional pairs that interfered with the baseline pairs. Multivariate, partial least-squares analysis supported a MS/DB-dependent functional network: MS/DB activity covaried with activity in areas important to selective attention, including intraparietal sulcus, and memory that are direct cholinergic efferents of the MS/DB, including the hippocampus, as well as the ventrolateral prefrontal cortex, implicated in PI resolution. This network was associated with effective PI-resolution behavior. A second network also correlated with PI resolution but appearing not to be driven by the MS/DB, included the lateral orbitofrontal cortex. Patients with compromised BF function did not engage the MS/DB-dependent network reliably; instead their PI-resolution behavior was well explained by the second network. Thus, 2 functional networks may underly a single cognitive function; when the MS/DB-dependent attention/memory integration network is compromised, an alternate network is available to maintain normal levels of performance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1047-3211
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1650-63
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Two distinct functional networks for successful resolution of proactive interference.
pubmed:affiliation
The Rotman Research Institute-Baycrest Centre, 3560 Bathurst St., Toronto, Ontario M6A 2E1, Canada. jcaplan@ualberta.ca
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't