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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
38
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pubmed:dateCreated |
2006-9-20
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pubmed:abstractText |
beta-Arrestins mediate internalization of plasma membrane receptors. Nephrin, a structural component of the glomerular slit diaphragm, is a single transmembrane spanning receptor and belongs to the family of adhesion molecules. Its mutation causes a hereditary nephrotic syndrome. We report the previously undescribed interaction of beta-arrestin2 with the nephrin C terminus. The phosphorylation status of nephrin Y1193 regulates inversely the binding of beta-arrestin2 and podocin. The Src-family member Yes, known to enhance podocin-nephrin interaction by nephrin phosphorylation, diminishes beta-arrestin2-nephrin interaction. beta-Arrestin2 induces nephrin endocytosis and attenuates nephrin signaling. This finding suggests that nephrin Y1193 serves as a molecular switch that determines the integrity of the slit diaphragm by functional competition between beta-arrestin2 and podocin. This concept offers a molecular pathomechanism of slit diaphragm distortion and opens therapeutic avenues for glomerular diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-10514378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-10742096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-10972661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-11259620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-11317351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-11562357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-11733553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-11861753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-12424224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-12660326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-12663475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-12668668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-12846735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-12958351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-12958364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-12958365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-14633607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-14701729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-15153549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-15579503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-15683363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-15699339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-15843475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-15845844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-16571882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-7574193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-7958873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16968782-9660941
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14110-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16968782-Amino Acid Sequence,
pubmed-meshheading:16968782-Animals,
pubmed-meshheading:16968782-Arrestins,
pubmed-meshheading:16968782-Cell Line,
pubmed-meshheading:16968782-Endocytosis,
pubmed-meshheading:16968782-Humans,
pubmed-meshheading:16968782-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16968782-Kidney Glomerulus,
pubmed-meshheading:16968782-Membrane Proteins,
pubmed-meshheading:16968782-Mice,
pubmed-meshheading:16968782-Molecular Sequence Data,
pubmed-meshheading:16968782-Phosphorylation,
pubmed-meshheading:16968782-Podocytes,
pubmed-meshheading:16968782-Point Mutation,
pubmed-meshheading:16968782-Protein Binding,
pubmed-meshheading:16968782-Protein Structure, Tertiary,
pubmed-meshheading:16968782-Recombinant Fusion Proteins,
pubmed-meshheading:16968782-Signal Transduction
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pubmed:year |
2006
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pubmed:articleTitle |
beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity.
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pubmed:affiliation |
Department of Nephrology, Marienhospital Herne, Hospital of the University of Bochum, D-44625 Herne, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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