Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1990-9-20
pubmed:abstractText
Escherichia coli responds to superoxide-generating agents by inducing approximately 40 proteins. We have identified a genetic locus, soxR (superoxide response), that positively regulates 9 of these proteins during superoxide stress. Induction under soxR control is at the transcriptional level, as shown with lac fusions to five paraquat-inducible promoters. Members of the soxR regulon include at least three proteins with demonstrable antioxidant roles: Mn-containing superoxide dismutase (which destroys superoxide radicals), endonuclease IV (which repairs radical-induced damages in DNA), and glucose-6-phosphate dehydrogenase (which produces NADPH). Induction of the soxR regulon also leads to diminished levels of the major outer membrane protein OmpF and alteration of the small-subunit ribosomal protein S6. These latter changes confer resistance to a variety of antibiotics. The soxR regulon may thus operate as an inducible defense against xenobiotics in general.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2430946, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2437576, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2453510, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2464796, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2472381, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2537820, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2644229, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2838846, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2847922, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2848006, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-2988786, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3011417, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3022287, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3052269, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3080354, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3279033, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3321061, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3539918, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-386035, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3884598, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3897198, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3897218, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-3904630, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-4196244, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-4564298, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-4943714, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-6099322, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-6201848, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-6273577, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-6309739, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-6348505, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-6348554, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-7007341, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-7021856, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696718-7035210
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents, http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants, http://linkedlifedata.com/resource/pubmed/chemical/DNA Transposable Elements, http://linkedlifedata.com/resource/pubmed/chemical/DNA-(Apurinic or Apyrimidinic..., http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonuclease IV (Phage..., http://linkedlifedata.com/resource/pubmed/chemical/Endodeoxyribonucleases, http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Glucosephosphate Dehydrogenase, http://linkedlifedata.com/resource/pubmed/chemical/Methylnitronitrosoguanidine, http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase, http://linkedlifedata.com/resource/pubmed/chemical/Superoxides, http://linkedlifedata.com/resource/pubmed/chemical/endonuclease IV, E coli
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6181-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:1696718-Anti-Bacterial Agents, pubmed-meshheading:1696718-Antioxidants, pubmed-meshheading:1696718-Chromosome Deletion, pubmed-meshheading:1696718-Cloning, Molecular, pubmed-meshheading:1696718-DNA Transposable Elements, pubmed-meshheading:1696718-DNA-(Apurinic or Apyrimidinic Site) Lyase, pubmed-meshheading:1696718-Deoxyribonuclease IV (Phage T4-Induced), pubmed-meshheading:1696718-Drug Resistance, Microbial, pubmed-meshheading:1696718-Endodeoxyribonucleases, pubmed-meshheading:1696718-Escherichia coli, pubmed-meshheading:1696718-Escherichia coli Proteins, pubmed-meshheading:1696718-Gene Expression Regulation, Bacterial, pubmed-meshheading:1696718-Genes, Bacterial, pubmed-meshheading:1696718-Genes, Regulator, pubmed-meshheading:1696718-Glucosephosphate Dehydrogenase, pubmed-meshheading:1696718-Methylnitronitrosoguanidine, pubmed-meshheading:1696718-Operon, pubmed-meshheading:1696718-R Factors, pubmed-meshheading:1696718-Superoxide Dismutase, pubmed-meshheading:1696718-Superoxides, pubmed-meshheading:1696718-Transduction, Genetic
pubmed:year
1990
pubmed:articleTitle
Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli.
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