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rdf:type |
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lifeskim:mentions |
umls-concept:C0000768,
umls-concept:C0004927,
umls-concept:C0017262,
umls-concept:C0027651,
umls-concept:C0030274,
umls-concept:C0185117,
umls-concept:C0205210,
umls-concept:C0332281,
umls-concept:C0521425,
umls-concept:C1101610,
umls-concept:C1521733,
umls-concept:C2348519,
umls-concept:C2911684
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pubmed:issue |
29
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|
pubmed:dateCreated |
2006-10-9
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|
pubmed:abstractText |
We investigated the global microRNA expression patterns in normal pancreas, pancreatic endocrine tumors and acinar carcinomas to evaluate their involvement in transformation and malignant progression of these tumor types. MicroRNAs are small noncoding RNAs that regulate gene expression by targeting specific mRNAs for degradation or translation inhibition. Recent evidence indicates that microRNAs can contribute to tumor development and progression and may have diagnostic and prognostic value in several human malignancies.
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pubmed:grant |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Oct
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:BersaniSamanthaS,
pubmed-author:CalinGeorge AdrianGA,
pubmed-author:CapelliPaolaP,
pubmed-author:CroceCarlo MCM,
pubmed-author:FalconiMassimoM,
pubmed-author:HaganJohn PJP,
pubmed-author:LiuChang-GongCG,
pubmed-author:MissiagliaEdoardoE,
pubmed-author:RoldoClaudiaC,
pubmed-author:ScarpaAldoA,
pubmed-author:VoliniaStefanoS
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|
pubmed:issnType |
Electronic
|
|
pubmed:day |
10
|
|
pubmed:volume |
24
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
4677-84
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16966691-Carcinoma, Acinar Cell,
pubmed-meshheading:16966691-Cell Transformation, Neoplastic,
pubmed-meshheading:16966691-Gene Expression Profiling,
pubmed-meshheading:16966691-Humans,
pubmed-meshheading:16966691-Insulinoma,
pubmed-meshheading:16966691-Liver Neoplasms,
pubmed-meshheading:16966691-MicroRNAs,
pubmed-meshheading:16966691-Pancreas,
pubmed-meshheading:16966691-Pancreatic Neoplasms,
pubmed-meshheading:16966691-Prognosis,
pubmed-meshheading:16966691-Survival
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|
pubmed:year |
2006
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pubmed:articleTitle |
MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior.
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pubmed:affiliation |
Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
