16966622

Source:http://linkedlifedata.com/resource/pubmed/id/16966622

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007587, umls-concept:C0007634, umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0035335, umls-concept:C0181586, umls-concept:C0812222, umls-concept:C1328819
pubmed:issue	9
pubmed:dateCreated	2006-9-12
pubmed:abstractText	To determine the efficacy of inducing p53-mediated cell death in retinoblastoma cells by Nutlin 3A, a small molecule HDM2 inhibitor.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7706534
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Annexin A5, http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/MDM2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Piperazines, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-mdm2, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53, http://linkedlifedata.com/resource/pubmed/chemical/nutlin 3
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0003-9950
pubmed:author	pubmed-author:AbramsonDavid HDH, pubmed-author:ClarosNidiaN, pubmed-author:CobrinikDavidD, pubmed-author:ElisonJasmine RJR, pubmed-author:LeeThomas CTC
pubmed:issnType	Print
pubmed:volume	124
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1269-75
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16966622-Annexin A5, pubmed-meshheading:16966622-Apoptosis, pubmed-meshheading:16966622-Blotting, Western, pubmed-meshheading:16966622-Cell Survival, pubmed-meshheading:16966622-Dose-Response Relationship, Drug, pubmed-meshheading:16966622-Flow Cytometry, pubmed-meshheading:16966622-Fluorescent Antibody Technique, Indirect, pubmed-meshheading:16966622-Humans, pubmed-meshheading:16966622-Imidazoles, pubmed-meshheading:16966622-Microscopy, Confocal, pubmed-meshheading:16966622-Phosphorylation, pubmed-meshheading:16966622-Piperazines, pubmed-meshheading:16966622-Proto-Oncogene Proteins c-mdm2, pubmed-meshheading:16966622-RNA, Small Interfering, pubmed-meshheading:16966622-Retinal Neoplasms, pubmed-meshheading:16966622-Retinoblastoma, pubmed-meshheading:16966622-Tumor Cells, Cultured, pubmed-meshheading:16966622-Tumor Suppressor Protein p53, pubmed-meshheading:16966622-Up-Regulation
pubmed:year	2006
pubmed:articleTitle	Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells.
pubmed:affiliation	Department of Ophthalmology, Weill Medical College of Cornell University, New York Presbyterian Hospital, 520 E. 70th Street, New York, NY 10021, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't